Browsing Research Units by Author "Crovella, Sergio"
Now showing items 1-10 of 10
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Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
Suleman, Muhammad; Murshed, Abduh; Imran, Kashif; Khan, Abbas; Ali, Zafar; Albekairi, Norah A; Wei, Dong-Qing; Yassine, Hadi M; Crovella, Sergio... more authors ... less authors ( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Analysis of E2F1 single-nucleotide polymorphisms reveals deleterious non-synonymous substitutions that disrupt E2F1-RB protein interaction in cancer
Muhammad, Suleman; Khattak, Aishma; Akbar, Fazal; Rizwan, Muhammad; Tayyab, Muhammad; Yousaf, Muhammad; Khan, Abbas; Albekairi, Norah A.; Agouni, Abdelali; Crovella, Sergio... more authors ... less authors ( Elsevier , 2024 , Article)Cancer is a medical condition that is caused by the abnormal growth and division of cells, leading to the formation of tumors. The E2F1 and RB pathways are critical in regulating cell cycle, and their dysregulation can ... -
Clinical and molecular characterization of hidradenitis suppurativa: a practical framework for novel therapeutic targets.
Moltrasio, Chiara; Tricarico, Paola Maura; Moura, Ronald; Brandao, Lucas André Cavalcanti; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Karger Publishers , 2023 , Report)Background: The pathophysiological picture underlying hidradenitis suppurativa (HS) and its syndromic forms is still patchy, thus presenting a great challenge for dermatologists and researchers since just by better ... -
Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients
Isaifan, Dina; Crovella, Sergio; Soubra, Lama; Al-Nesf, Maryam; Steinhoff, Martin ( MDPI , 2023 , Article Review)Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ... -
Impacts on Student Learning and Skills and Implementation Challenges of Two Student-Centered Learning Methods Applied in Online Education
soubra, lama; al Ghouti, Mohamed; Abu diyeh, Mohamed; Crovella, sergio; Abou saleh, Haissam ( MDPI , 2022 , Article)Online education became more prevalent during the COVID-19 pandemic in many countries around the world, including the Gulf Cooperation Council (GCC) countries. This study aims at assessing the impacts on learning and skills ... -
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
de Oliveira, Ana Sofia Lima Estevao; de Siqueira, Roberta Cardoso; Nait-Meddour, Cécile; Tricarico, Paola Maura; Moura, Ronald; Agrelli, Almerinda; d'Adamo, Adamo Pio; Jamain, Stéphane; Crovella, Sergio; de Fátima Medeiros Brito, Maria; Boniotto, Michele; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Wiley , 2023 , Article)Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ... -
Microalgae potential to protect from heavy metals-induced carcinogenicity
Hadjira, Hamai-Amara; Abou-Saleh, Haissam; A. Al-Ghouti, Mohammad; Crovella, Sergio; Saadaoui, Imen; Soubra, Lama... more authors ... less authors ( Elsevier , 2024 , Article)Toxic elements are present naturally in the environment; however, during the last century, their level has been continuously rising in the air, water, and soil due to anthropogenic activities, including urban runoff, ... -
The mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons
Zupin, Luisa; Crovella, Sergio; Milena, Cadenaro; Barbi, Egidio; Celsi, Fulvio ( Wiley , 2023 , Article)Photobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. ... -
Nanomedicine as a Potential Tool against Monkeypox.
Mohamed, Nura Adam; Zupin, Luisa; Mazi, Sarah Ismail; Al-Khatib, Hebah A; Crovella, Sergio ( MDPI , 2023 , Article Review)Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ... -
Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases
Mohamed, Nura A.; Marei, Isra; Crovella, Sergio; Abou-Saleh, Haissam ( MDPI , 2022 , Article)Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. However, despite the recent developments in the management of CVDs, the early and long outcomes vary considerably in patients, ...