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Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.
(
BMC
, 2020 , Article Review)
Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia ...
Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
(
Frontiers Media
, 2021 , Article)
A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer ...
Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors
(
Qatar University Press
, 2021 , Poster)
Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI ...
Role of NAD+ in regulating cellular and metabolic signaling pathways
(
Elsevier
, 2021 , Article Review)
BackgroundNicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved in a myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ is often ...
miRNAs as novel immunoregulators in cancer
(
Elsevier
, 2021 , Article Review)
The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...
The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases
(
Springer Science and Business Media Deutschland GmbH
, 2022 , Article Review)
Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several studies in the Arab world, but the frequency and spectrum of these translocations ...
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids
(
Elsevier
, 2021 , Article)
Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, ...
Nanomedicine for Cancer.
(
Bentham Science Publishers
, 2022 , Other)
Over the past decades, oncology has occupied the lion’s share of all nanomedical applications [1-3]. In 2020, up to 65% of the clinical trials involving nanomaterials were
attending to cancer therapeutics and diagnostics ...
The power of phytochemicals combination in cancer chemoprevention
(
Ivyspring International Publisher
, 2020 , Article Review)
Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...
Epac as a tractable therapeutic target
(
Elsevier
, 2023 , Article)
In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ...