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المؤلفBansode, R. R.
المؤلفLeung, T.
المؤلفRandolph, P.
المؤلفWilliams, L. L.
المؤلفAhmedna, M.
تاريخ الإتاحة2015-11-05T10:06:04Z
تاريخ النشر2013
اسم المنشورFood Science & Nutrition
المصدرWiley Online library
الاقتباسBansode, R. R., Leung, T., Randolph, P., Williams, L. L. and Ahmedna, M. (2013), Cinnamon extract inhibits angiogenesis in zebrafish and human endothelial cells by suppressing VEGFR1, VEGFR2, and PKC-mediated MAP kinase. Food Science & Nutrition, 1: 74–82.
الرقم المعياري الدولي للكتاب2048-7177
معرّف المصادر الموحدhttp://dx.doi.org/10.1002/fsn3.13
معرّف المصادر الموحدhttp://hdl.handle.net/10576/3688
الملخصAngiogenesis is a process of new blood vessel generation and under pathological conditions, lead to tumor development, progression, and metastasis. Many bioactive components have been studied for its antiangiogenic properties as a preventive strategy against tumor development. This study is focused on the effects of cinnamon extract in modulating the pathway involved in angiogenesis. Human umbilical vein endothelial cells (HUVEC) were treated with cinnamon extract at a concentration of 25 μg/mL for 1, 3, or 6 h followed by treatment with phorbol ester (TPA) at a concentration of 10 nmol/L to induce mitogen-activated protein kinase (MAPK) expression. Results show that cinnamon extract inhibited TPA-induced phosphorylation of MAPK and AKT in a dose-dependent manner. Gene expression results in HUVEC showed that cinnamon extract treatment inhibited TPA induction of protein kinase C, PKCα and PKCη messenger RNA (mRNA) expression in a dose-dependent manner along with suppression of vascular endothelial growth factor receptor 1 (VEGFR1/Flt1) and vascular endothelial growth factor receptor 2 (VEGFR2/KDR/Flk1) mRNA expression. Cinnamon extract was administered to zebrafish embryos during gastrulation at 6–8 h post fertilization (hpf). The embryos were observed for changes in morphology, toxicity, and blood vessel development. The intersegmental vessels in the zebrafish embryos were attenuated and underdeveloped at an effective cinnamon extract dose of 250 μg/mL compared with the DMSO-treated control. Exposure to cinnamon extract for 36 h resulted in gross morphological deformities. The results suggest the effect of cinnamon extract on angiogenesis is mediated by PKC-dependent phosphorylation of MAPK.
راعي المشروعCenter for Excellence in Post-Harvest Technologies
اللغةen
الناشرWiley Periodicals, Inc.
الموضوعAngiogenesis
cinnamon
mitogen-activated protein kinase
protein kinase C
vascular endothelial growth factor receptor
العنوانCinnamon extract inhibits angiogenesis in zebrafish and human endothelial cells by suppressing VEGFR1, VEGFR2, and PKC-mediated MAP kinase
النوعArticle
رقم العدد1
رقم المجلد1
dc.accessType Abstract Only


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