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AuthorMalki, Ahmed
AuthorAziz, Hassan
AuthorMohsen, Mona O.
Available date2015-11-05T10:18:00Z
Publication Date2015-03
Publication NameClon Transgen
CitationMalki AM, Aziz HA, Mohsen MO (2015) Vascular Endothelial Growth Factor Inhibitors: Blocking Angiogenesis and Improving Outcomes. Clon Transgen 4:e116.
ISSN2168-9849
URIhttp://dx.doi.org/10.4172/2168-9849.1000e116
URIhttp://hdl.handle.net/10576/3706
AbstractTumor tissues are just like normal tissues; require nutrients, oxygen and the ability to evacuate waste products and CO2, the process of angiogenesis or (tumor-associated vascularization) addresses these needs to tumor tissues. The process of angiogenesis in tumors is continuously activated; triggering the normal vasculature to sprout out new vessels to sustain the tumor growth. The resulting new blood vessels “feed” growing tumors with oxygen and nutrients, allowing the cancer cells to invade nearby tissue and metastasize around, forming new colonies of cancer cells. This process is governed by several inducing and opposing factors, some of these factors are signaling proteins, which bind to the cell-surface receptors on the vascular endothelial cells causing their stimulation or inhibition. Vascular Endothelial Growth Factor-
Languageen
PublisherOMICS International
SubjectCancer cells
angiogenesis
angiogenesis inhibitors
TitleEditorial: Vascular Endothelial Growth Factor Inhibitors: Blocking Angiogenesis and Improving Outcomes.
TypeArticle
Issue Number1
Volume Number4
dc.accessType Open Access


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