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AuthorRahmani, Jamal
AuthorRoudsari, Arezoo Haghighian
AuthorBawadi, Hiba
AuthorClark, Cain
AuthorRyan, Paul M.
AuthorSalehisahlabadi, Ammar
AuthorRahimi sakak, Fatemeh
AuthorGoodarzi, Naser
AuthorRazaz, Jalaledin Mirzay
Available date2022-12-27T10:51:16Z
Publication Date2022
Publication NameNutritional Neuroscience
AbstractObjective: Inconsistent results regarding the association between the Body Mass Index (BMI) and brain disorders have been reported. We performed this study to investigate the association between BMI and risk of Parkinson, Alzheimer, Dementia and Dementia-mortality. Methods: A systematic search was conducted up to April 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane Library. Results pooled with random-effects model. Results: Totally, 29 articles which were included in this study with4,978,621 participants. The pooled HR for Parkinson's in the underweight person was 1.20 (95%CI1.10-1.30). The pooled HR for dementia in underweight and overweight category was 1.23 (95%CI = 1.05-1.45) and 0.88 (95%CI = 0.83-0.94), respectively. There is not any significant relation between each categories of BMI and Alzheimer disease. The pooled HR for dementia in underweight and overweight category was 1.36 (95%CI = 1.14-1.63) and 0.81 (95%CI = 0.49-1.33), respectively. The non-linear association between BMI and risk of Dementia-mortality was significant (p = 0.001,Coeff = 0.003). Conclusion: This study highlights underweight related to increase incidence of Parkinson, Dementia, and Dementia mortality but no on Alzheimer disease. 2020 Informa UK Limited, trading as Taylor & Francis Group.
SponsorThe student research committee at Shahid Beheshti University of Medical Sciences was the financial supporter of this study (19222).
PublisherTaylor and Francis Ltd.
SubjectAlzheimer's disease
body fat
Body mass index
Parkinson's disease
TitleBody mass index and risk of Parkinson, Alzheimer, Dementia, and Dementia mortality: a systematic review and dose-response meta-analysis of cohort studies among 5 million participants
TypeArticle Review
Issue Number3
Volume Number25

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