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المؤلفRahmani, Jamal
المؤلفHaghighian Roudsari, Arezoo
المؤلفBawadi, Hiba
المؤلفThompson, Jacqueline
المؤلفKhalooei Fard, Razieh
المؤلفClark, Cain
المؤلفRyan, Paul M.
المؤلفAjami, Marjan
المؤلفRahimi Sakak, Fatemeh
المؤلفSalehisahlabadi, Ammar
المؤلفAbdulazeem, Hebatullah M.
المؤلفJamali, Mohammad Reza
المؤلفMirzay Razaz, Jalaledin
تاريخ الإتاحة2022-12-27T10:51:16Z
تاريخ النشر2020
اسم المنشورThrombosis Research
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.thromres.2020.05.014
معرّف المصادر الموحدhttp://hdl.handle.net/10576/37675
الملخصBackground: The relationship between body mass index (BMI) and risk of venous thromboembolism (VTE) and pulmonary embolism (PE) is a controversial issue. This dose-response meta-analysis was performed to investigate the association between BMI and risk of VTE and PE incidence based on cohort studies. Method: A comprehensive systematic search was conducted up to August 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane. DerSimonian and Laird random-effects models were run to estimate combined hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out based on BMI values. Results: Eleven articles with 16 arms and 3,910,747 participants were eligible for inclusion in this systematic review and meta-analysis. Pooled results showed a positive association between BMI and risk of VTE in the obese participants compared to participants classified in the normal BMI category (HR: 1.62, 95% CI: 1.29-2.04, I2 = 95%). Furthermore, results showed a significant association between lower BMI (underweight versus normal BMI category) and reduced risk of PE (HR: 0.80, 95% CI: 0.70-0.92, I2 = 9%) and higher risk of PE in obese versus normal BMI participants (HR: 2.24, 95% CI: 1.93-2.60, I2 = 0%). There was a significant linear relationship between BMI and risk of VTE (p < 0.001) and PE (p < 0.001). Conclusions: This systematic review and dose-response meta-analysis with 3,910,747 participants highlights obesity as a significant risk factor related to the incidence of VTE and PE. 2020 Elsevier Ltd
راعي المشروعThe student research committee at Shahid Beheshti University of Medical Sciences was the financial supporter of this study (19163).
اللغةen
الناشرElsevier
الموضوعBody mass index
Pulmonary embolism
Venous thromboembolism
العنوانRelationship between body mass index, risk of venous thromboembolism and pulmonary embolism: A systematic review and dose-response meta-analysis of cohort studies among four million participants
النوعArticle Review
الصفحات64-72
رقم المجلد192
dc.accessType Abstract Only


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