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AuthorWang, Jason
AuthorYan, Alice F.
AuthorCheskin, Lawrence J.
AuthorShi, Zumin
Available date2022-12-29T10:59:31Z
Publication Date2022
Publication NameNutrients
CitationWang, J.; Yan, A.F.; Cheskin, L.J.; Shi, Z. Higher Serum Testosterone Level Was Associated with a Lower Risk of Prediabetes in US Adults: Findings from Nationally Representative Data. Nutrients 2023, 15, 9. https://doi.org/10.3390/nu15010009
URIhttp://hdl.handle.net/10576/37875
AbstractLow testosterone may be a novel risk factor for prediabetes. We assessed the associations between prediabetes and total serum testosterone (TT), and whether the associations were modified by population characteristics. The data from 5330 adults aged ≥ 20 years, who participated in the 2011–2016 National Health and Nutrition Examination Survey in the United States, were used. Prediabetes was based on fasting plasma glucose, HbA1c, or OGTT. Sociodemographic, obesity, co-morbidities, and lifestyle factors were included in logistic regression models. A dose-response relationship was found between prediabetes and the testosterone quartiles. The odds ratio (OR and 95% CI) for prediabetes across the quartiles of TT were: 1.00, 0.68 (0.50–0.92), 0.51 (0.36–0.72), and 0.48 (0.34–0.70) in men; and 1.00, 1.06 (0.81–1.40), 0.81 (0.61–1.06), and 0.68 (0.49–0.93) in women. The results changed marginally if the models were adjusted for additional variables such as BMI. The subgroup analyses showed differences in the association, which was stronger in some groups (for men: age < 50, white and black, overweight/obese, adequate physical activity, never-smoking; and for women: age ≥ 50, black). A higher testosterone level was associated with a lower risk of prediabetes among US adults. The strength of the association varied by population characteristics, weight status, gender, and lifestyle factors.
Languageen
PublisherMDPI
Subjectdiabetes
prediabetes
testosterone
TitleHigher Serum Testosterone Level Was Associated with a Lower Risk of Prediabetes in US Adults: Findings from Nationally Representative Data
TypeArticle
Issue Number1
Volume Number15
ESSN2072-6643
dc.accessType Open Access


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