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AuthorMkrtchyan, Satenik
AuthorJakubczyk, Michał
AuthorLanka, Suneel
AuthorYar, Muhammad
AuthorAyub, Khurshid
AuthorShkoor, Mohanad
AuthorPittelkow, Michael
AuthorIaroshenko, Viktor O.
Available date2023-01-23T10:54:33Z
Publication Date2021-12-21
Publication NameAdvanced Synthesis and Catalysis
Identifierhttp://dx.doi.org/10.1002/adsc.202100538
CitationS. Mkrtchyan, M. Jakubczyk, S. Lanka, M. Yar, K. Ayub, M. Shkoor, M. Pittelkow, V. O. Iaroshenko, Adv. Synth. Catal. 2021, 363, 5448.
ISSN16154150
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85116867361&origin=inward
URIhttp://hdl.handle.net/10576/38727
AbstractWe communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C−F bond activation, accompanied with utilisation of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF3 group into other functionalities. (Figure presented.).
SponsorThis research project was supported by a grant from National Science Centre (NSC) Poland, the SONATA 10 (Nr. 2015/19/D/ST5/02774) obtained by Dr. Viktor Iaroshenko. The salary of Dr. Satenik Mkrtchyan was covered by a grant from National Science Centre (NSC) Poland within the framework of European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement Nr. 665778 (POLONEZ 2 grant, Nr. 2016/21/P/ST5/00630). Professor Michael Pittelkow appreciates the support from the Danish Council for Independent Research (DFF 4181-00206 and 9040-00265) and from the University of Copenhagen.
Languageen
PublisherWiley
SubjectC−F bond activation
Fluorine
Mechanochemistry
Methodology
Ytterbia
TitleMechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases
TypeArticle
Pagination5448-5460
Issue Number24
Volume Number363
ESSN1615-4169
dc.accessType Open Access


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