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AuthorShamshad, B.
AuthorJamal, R.A.
AuthorAshiqa, U.
AuthorMahrooof-Tahirb, M.
AuthorShaikha, Z.
AuthorSultana, S.
AuthorKhanc, K.M.
Available date2015-12-15T06:52:47Z
Publication Date2015-12
Publication NameMedicinal Chemistry
ResourceScopus
CitationShamshad, Bushra et al. "Studies on Chemistry, Spectroscopy and Antioxidant Activities of Chromium(III)-Hydrazide Complexes", Medicinal Chemistry, 2015 11:8, 798-806.
ISSN1573-4064
URIhttp://dx.doi.org/10.2174/1573406411666150401103442
URIhttp://hdl.handle.net/10576/3949
AbstractAcid hydrazides are vital chemical entities due to their biological activities. Upon complexation with certain metal ions, their biological activities are known to be positively enhanced. The present work describes the synthesis of Cr(III)-hydrazide complexes, and their structural, spectroscopic and antioxidant properties to reveal their chemistry and biochemistry. Physical (magnetic moment, conductivity measurements), analytical (C, H, N and Cr analysis) and spectral (EI-Mass, FTIR) techniques are used for the characterization of synthesized compounds. All Cr(III)-hydrazide complexes exhibit octahedral geometry with general formula [Cr(L)2(H2O)2]Cl3. In these complexes, the hydrazide ligands are coordinated via carbonyl oxygen and terminal amino nitrogen in a bidentate fashion. All Cr(III)-hydrazide complexes were screened for in vitro diphenyldipicryl hydrazine (DPPH), superoxide dismutase and nitric oxide radical scavenging activities. Majority of the Cr(III)-hydrazide complexes were found to be more potent scavengers than their uncoordinated hydrazide ligands. This study demonstrates an interesting structure-activity relationship (SAR) which is presented here.
Languageen
PublisherBentham Science Publishers B.V.
SubjectAntioxidants
Chromium(III)-hydrazide complex
DPPH radical
Nitric oxide
Superoxide
TitleStudies on chemistry, spectroscopy and antioxidant activities of chromium(III)-hydrazide complexes
TypeArticle
Pagination798-806
Issue Number8
Volume Number11
dc.accessType Abstract Only


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