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المؤلفBen Hsouna, Anis
المؤلفMongi, Saoudi
المؤلفCulioli, Gerald
المؤلفBlache, Yves
المؤلفGhlissi, Zohra
المؤلفChaabane, Rim
المؤلفEl Feki, Abdelfattah
المؤلفJaoua, Samir
المؤلفTrigui, Mohamed
تاريخ الإتاحة2015-12-21T10:39:41Z
تاريخ النشر2013-11
اسم المنشورToxicology and Industrial Healthen_US
الاقتباسBen Hsouna A, Mongi S, Culioli G, Blache Y, Ghlissi Z, Chaabane R, El Feki A, Jaoua S, Trigui M., "Protective effects of ethyl acetate fraction of Lawsonia inermis fruits extract against carbon tetrachloride-induced oxidative damage in rat liver", Toxicology and Industrial Health, 2013 Nov 8.
الرقم المعياري الدولي للكتاب0748-2337
الرقم المعياري الدولي للكتاب1477-0393 (online)
معرّف المصادر الموحدhttp://dx.doi.org/10.1177/0748233713502839
معرّف المصادر الموحدhttp://hdl.handle.net/10576/3969
الملخصThis study aimed to investigate the antioxidant properties of different fractions obtained from the fruits of Lawsonia inermis, a widely used medicinal plant, against carbon tetrachloride (CCl4)-induced oxidative stress in rat liver. The results show that several fractions obtained from L. inermis fruits possessed important antioxidant activity. Among them, the ethyl acetate (EA) fraction showed the highest antioxidant activity. Then, EA fraction was selected for the purification of potential antioxidant compounds. The hepatoprotective effects of EA fraction and its most active constituent, gallic acid (GA), were evaluated against CCl4-induced hepatotoxicity in rats. CCl4 induced oxidative stress by a significant rise in serum marker enzymes. However, pretreatment of rats with EA fraction of fruits of L. inermis at a dose of 250 mg kg-1 body weight and GA significantly lowered some serum biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase) in treated rats. A significant reduction in hepatic thiobarbituric acid reactive substances and an increase in antioxidant enzymes namely superoxide dismutase, catalase, and glutathione peroxidase by treatment with plant extract and GA, against CCl4-treated rats, were observed. Histopathological examinations showed extensive liver injuries, characterized by extensive hepatocellular necrosis, vacuolization, and inflammatory cell infiltration. This potential antioxidant activity is comparable to those of the major purified antioxidant compound, GA. Based on these results, it was observed that fruits of L. inermis protect liver from oxidative stress induced by CCl4 and thus help in evaluation of traditional claim on this plant.
راعي المشروعTunisian Ministry of Higher Education
اللغةen
الناشرSAGE Publications
الموضوعLawsonia inermis
الموضوعHepato toxicity
الموضوعCarbon tetrachloride
الموضوعOxidative stress
الموضوعBeneficial effect
العنوانProtective effects of ethyl acetate fraction of Lawsonia inermis fruits extract against carbon tetrachloride-induced oxidative damage in rat liver
النوعArticle


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