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المؤلفNashwan, Abdulqadir J.
المؤلفYassin, Mohamed A.
المؤلفAbd-Alrazaq, Alaa
المؤلفShuweihdi, Farag
المؤلفOthman, Muftah
المؤلفAbdul Rahim, Hanan F.
المؤلفShraim, Mujahed
تاريخ الإتاحة2023-02-20T05:47:05Z
تاريخ النشر2023-01-01
اسم المنشورHemodialysis International
المعرّفhttp://dx.doi.org/10.1111/hdi.13054
الاقتباسNashwan, AJ, Yassin, MA, Abd-Alrazaq, A, Shuweihdi, F, Othman, M, Abdul Rahim, HF, et al. Hepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta-analysis. Hemodialysis International. 2023; 27( 1): 3– 11. https://doi.org/10.1111/hdi.13054
الرقم المعياري الدولي للكتاب14927535
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85142303663&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40155
الملخصIntroduction: Few studies have reported hepatic and cardiac iron overload in patients with end-stage renal disease (ESRD), and the current evidence regarding the prevalence is still scarce. Aim: This review aims to estimate the prevalence of hepatic and/or cardiac iron overload quantified by magnetic resonance imaging (MRI) in patients with ESRD who receive hemodialysis (HD), peritoneal dialysis (PD), or have undergone a kidney transplant. Methods: A systematic review with meta-analysis was conducted and reported in line with PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. MEDLINE and Embase bibliographic databases were searched using a comprehensive list of controlled vocabulary and keywords to identify relevant studies. All studies reporting the prevalence of hepatic and/or cardiac iron overload quantified by MRI in ESRD patients were considered. The Newcastle-Ottawa scale was used to assess the methodological quality of included studies. To investigate the heterogeneity between studies, random-effect meta-analyses for proportions were used. Results: The review comprised seven studies that included 339 patients. Using meta-analysis, the pooled prevalence of severe and mild to moderate hepatic iron overload quantified by MRI was 0.23 [95% CI: 0.08–0.43] and 0.52 [95% CI: 0.47–0.57], respectively. Only three studies included cardiac iron quantification, and none reported iron overload. Conclusions: This review has revealed a high prevalence of severe hepatic iron overload in patients with ESRD treated by HD. Further studies with a larger sample size are needed to determine the impact of iron overload on vital organs in patients with ESRD and guide future research in this understudied field. Proper use of iron chelation and continuous monitoring will help in the early detection of unsolicited complications; however, the low renal clearance of most iron chelators limits the options for treating iron excess in patients with ESRD.
راعي المشروعOpen Access funding was provided by the Qatar National Library.
اللغةen
الناشرWiley
الموضوعend-stage renal disease
heart
hemodialysis
iron overload
liver
meta-analysis
systematic review
T2*MRI
العنوانHepatic and cardiac iron overload quantified by magnetic resonance imaging in patients on hemodialysis: A systematic review and meta-analysis
النوعArticle Review
الصفحات3-11
رقم العدد1
رقم المجلد27
ESSN1542-4758
dc.accessType Open Access


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