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المؤلفFarooq, M.
المؤلفTaha, N.A.
المؤلفButorac, R.R.
المؤلفEvans, D.A.
المؤلفElzatahry, A.A.
المؤلفElsayed, E.A.
المؤلفWadaan, M.A.M.
المؤلفAl-Deyab, S.S.
المؤلفCowley, A.H.
تاريخ الإتاحة2015-12-29T12:54:36Z
تاريخ النشر2015-10
اسم المنشورInternational Journal of Molecular Sciences
المصدرScopus
الاقتباسFarooq M., Taha N.A., Butorac R.R., Evans D.A., Elzatahry A.A., Elsayed E.A., Wadaan M.A.M., Al-Deyab S.S., Cowley A.H., Biological screening of newly synthesized BIAN N-heterocyclic gold carbene complexes in zebrafish embryos, (2015) International Journal of Molecular Sciences, 16 (10), pp. 24718-24731.
الرقم المعياري الدولي للكتاب1422-0067
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/ijms161024718
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4017
الملخصN-Heterocyclic carbene (NHC) metal complexes possess diverse biological activities but have yet to be extensively explored as potential chemotherapeutic agents. We have previously reported the synthesis of a new class of NHC metal complexes N-Heterocyclic with acetate [IPr(BIAN)AuOAc] and chloride [IPr(BIAN)AuCl] ligands. In the experiments reported herein, the zebrafish embryos were exposed to serial dilutions of each of these complexes for 10-12 h. One hundred percent mortality was observed at concentrations ?50 ?M. At sub-lethal concentrations (10-30 ?M), both compounds influenced zebrafish embryonic development. However, quite diverse categories of abnormalities were found in exposed embryos with each compound. Severe brain deformation and notochord degeneration were evident in the case of [IPr(BIAN)AuOAc]. The zebrafish embryos treated with [IPr(BIAN)AuCl] exhibited stunted growth and consequently had smaller body sizes. A depletion of 30%-40% glutathione was detected in the treated embryos, which could account for one of the possible mechanism of neurotoxicity. The fact that these compounds are capable of both affecting the growth and also compromising antioxidant systems by elevating intracellular ROS production implies that they could play an important role as a new breed of therapeutic molecules.
راعي المشروعDeanship of Scientific Research at King Saud University for funding this research group No. RGP-284 and Robert A. Welch Foundation (Grant F-0003).
اللغةen
الناشرMDPI AG
الموضوعBIAN
N-heterocyclic carbenes complexes
Neurotoxicity
Oxidative stress
Zebrafish
العنوانBiological screening of newly synthesized BIAN N-heterocyclic gold carbene complexes in zebrafish embryos
النوعArticle
الصفحات24718-24731
رقم العدد10
رقم المجلد16


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