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    Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

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    s10006-022-01104-8.pdf (968.0Kb)
    Date
    2022-08-03
    Author
    Pérez-González, Fabián
    Abusamak, Mohammad
    Sáez-Alcaide, Luis Miguel
    García-Denche, Jesus Torres
    Marino, Faleh Ahmad Tamimi
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    Abstract
    Purpose: To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model. Methods: Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively. Results: Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72 h. Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0.008). Rescue medication consumption seemed to be comparable between groups. Conclusion: Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135327004&origin=inward
    DOI/handle
    http://dx.doi.org/10.1007/s10006-022-01104-8
    http://hdl.handle.net/10576/41417
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    • Dental Medicine Research [‎407‎ items ]

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