Browsing College of Medicine by Title
Now showing items 1323-1342 of 1439
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The role of antibiotic resistance mobile genetic element MCR-1 in enhancing bacterial survival in macrophages
( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Antimicrobial resistance (AMR) determinants such as mobile colistin resistance (MCR-1) that encodes colistin resistance are increasingly spreading in healthcare-associated and community-acquired infections. 1 ... -
The Role of Demographic and Clinical Characteristics in Distinguishing Testicular Torsion from Torsion of the Appendix Testis: A Single-center Retrospective Study
( Karolinum - Nakladatelstvi Univerzity Karlovy , 2023 , Article)The acute scrotum (AS) in the pediatric population is a medical emergency. AS is usually caused by testicular torsion (TT) and torsion of the appendix testis (TAT). The current study explored which demographic and clinical ... -
The Role of Epidermal Growth Factor Receptor Family of Receptor Tyrosine Kinases in Mediating Diabetes-Induced Cardiovascular Complications
( Frontiers Media S.A. , 2021 , Article)Diabetes mellitus is a major debilitating disease whose global incidence is progressively increasing with currently over 463 million adult sufferers and this figure will likely reach over 700 million by the year 2045. It ... -
The role of glycogen synthase kinase 3 (GSK3) in cancer with emphasis on ovarian cancer development and progression: A comprehensive review
( Association of Basic Medical Sciences of FBIH , 2021 , Article Review)Glycogen synthase kinase 3 (GSK3) is a monomeric serine-threonine kinase discovered in 1980 in a rat skeletal muscle. It has been involved in various cellular processes including embryogenesis, immune response, inflammation, ... -
The role of protein tyrosine phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance
( MDPI AG , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ... -
The role of Rezum in the management of refractory urinary retention due to benign prostate hyperplasia: A literature review
( Taylor and Francis Ltd. , 2023 , Article)Background: Benign prostatic hyperplasia is the most common cause of urinary retention in men (BPH). The gold standard surgical treatment is transurethral resection of the prostate (TURP). However, due to the morbidity and ... -
The Safety of Novel Therapies in Chronic Lymphocytic Leukemia in the Era of Intermittent Fasting: A Pharmacology-Based Review
( MDPI , 2024 , Article Review)Intermittent fasting (IF) has recently gained popularity due to its emerging benefits in reducing weight and improving metabolic health. Concurrently, novel agents (NAs) like venetoclax and Bruton tyrosine kinase inhibitors ... -
The unseen battle: A global call to safeguard the mental well-being of Palestinian children
( Elsevier , 2024 , Other)The long-standing and complex Israeli-Palestinian conflict has led to the widespread displacement of Palestinians and resulted in ongoing challenges for the Palestinian population (Feliciana, 2011). It has had a lasting ... -
Theranostic molecular profiling of pleomorphic ductal carcinoma of the breast.
( Wiley , 2019 , Other)Pleomorphic ductal carcinoma (PDC) is a very rare subtype of invasive ductal carcinoma of no‐special type (NST), characterized by the presence of highly atypical/bizarre (>6‐fold variation in nuclear size) and multinucleated ... -
The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
( Nature Research , 2021 , Article)Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the ... -
Therapeutic effects of statins on osteoarthritis: A review
( Wiley , 2022 , Article Review)Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ... -
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
( Elsevier , 2022 , Article)Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ... -
Therapeutic potential of resveratrol in covid-19-associated hemostatic disorders
( MDPI , 2021 , Article)Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19's outcome and severity. Dysfunctions of endothelial cells and platelets are tightly ... -
Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment
( American Society for Pharmacology and Experimental Therapy (ASPET) , 2023 , Article)Cardiovascular complications of diabetes and obesity remain a major cause for morbidity and mortality worldwide. Despite significant advances in the pharmacotherapy of metabolic disease, the available approaches do not ... -
This House believes that considering the continuous quarantine and precautionary measures should be of a priority over lifting the restrictions to avoid the negative economic and social consequences
( College of Medicine - Qatar University , 2020 , Video)NA -
Thrombin generation measured on ST Genesia, a new platform in the coagulation routine lab: Assessment of analytical and between-subject variation
( Wiley Open Access , 2022 , Article)Background: The thrombin generation (TG) assay, which measures global coagulation, has mainly been used as a research tool to investigate thrombotic and bleeding disorders. Recently, Diagnostica Stago launched the ST ... -
Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue
( MDPI , 2022 , Article)The increased global prevalence of metabolic disorders including obesity, insulin resistance, metabolic syndrome and diabetes is mirrored by an increased incidence of prostate cancer (PCa). Ample evidence suggests that ... -
Thrombosis Management and Challenges in COVID-19 Patients Presenting with Acute Coronary Syndromes.
( Medknow Publications , 2020 , Article)Thrombotic complications in patients with coronavirus disease 2019 (COVID-19) infection have been increasingly recognized, particularly those affecting the cardiovascular system. Patients with COVID-19 infection can suffer ... -
Thromboxane biosynthesis and future events in diabetes: the ASCEND trial
( Oxford University Press , 2024 , Article)Background and Thromboxane (TX) A2, released by activated platelets, plays an important role in atherothrombosis. Urinary 11-dehydro-Aims TXB2 (U-TXM), a stable metabolite reflecting the whole-body TXA2 biosynthesis, is ... -
Thujone inhibits the function of 7-nicotinic acetylcholine receptors and impairs nicotine-induced memory enhancement in one-trial passive avoidance paradigm
( Elsevier Ireland Ltd , 2017 , Article)Effects of thujone, a major ingredient of absinthe, wormwood oil and some herbal medicines, were tested on the function of 7 subunit of the human nicotinic acetylcholine (7 nACh) receptor expressed in Xenopus oocytes using ...