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AuthorAbusamak, Mohammad
AuthorAl-Tamimi, Mohammad
AuthorAl-Waeli, Haider
AuthorTahboub, Kawkab
AuthorCai, Wenji
AuthorMorris, Martin
AuthorTamimi, Faleh
AuthorNicolau, Belinda
Available date2023-05-11T12:06:13Z
Publication Date2023-01-01
Publication NameChronobiology International
Identifierhttp://dx.doi.org/10.1080/07420528.2023.2200495
CitationAbusamak, M., Al-Tamimi, M., Al-Waeli, H., Tahboub, K., Cai, W., Morris, M., ... & Nicolau, B. (2023). Chronotherapy in dentistry: A scoping review. Chronobiology International, 1-14.‏
ISSN07420528
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152916555&origin=inward
URIhttp://hdl.handle.net/10576/42650
AbstractThe circadian clock modulates almost all vital aspects of our physiology and metabolism, including processes relevant to dentistry, such as healing, inflammation and nociception. Chronotherapy is an emerging field aiming to improve therapeutic efficacy and decrease adverse effects on health outcomes. This scoping review aimed to systematically map the evidence underpinning chronotherapy in dentistry and to identify gaps in knowledge. We conducted a systematic scoping search using four databases (Medline, Scopus, CINAHL and Embase). We identified 3908 target articles screened by two blinded reviewers, and only original animal and human studies investigating the chronotherapeutic use of drugs or interventions in dentistry were included. Of the 24 studies included, 19 were human studies and five were animal studies. Chrono-radiotherapy and chrono-chemotherapy reduced treatment side effects and improved therapeutic response, leading to higher survival rates in cancer patients. Animal studies reported that tooth movement and periodontal tissue response to orthodontic forces follow a diurnal rhythm that might influence bone metabolism. Profound and prolonged local anesthesia could be achieved when injected in the evening. Although the overall quality of the included studies was low, chronotherapy applications in dentistry seem to have favourable outcomes, especially in head and neck cancer treatments.
Languageen
PublisherTaylor & Francis Group, LLC
Subjectchronobiology
circadian rhythm
dentistry
Drug chronotherapy
oral health
TitleChronotherapy in dentistry: A scoping review
TypeArticle
dc.accessType Open Access


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