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المؤلفOliva-Olivera, Wilfredo
المؤلفCoin-Araguez, Leticia
المؤلفSalas, Julian
المؤلفLhamyani, Said
المؤلفGentile, Adriana-Mariel
المؤلفGarcia, Esteban Sarria
المؤلفHmadcha, Abdelkrim
المؤلفZayed, Hatem
المؤلفVega-Rioja, Antonio
المؤلفTinahones, Francisco J.
المؤلفEl Bekay, Rajaa
تاريخ الإتاحة2016-03-31T14:00:57Z
تاريخ النشر2015-12
اسم المنشورPLoS ONE
المصدرScopus
الاقتباسOliva-Olivera W, Coin-Araguez L, Salas J, Lhamyani S, Gentile A-M, Sarria Garcia E, et al. (2015) Myocardial Ischemic Subject's Thymus Fat: A Novel Source of Multipotent Stromal Cells. PLoS ONE 10(12): e0144401.
الرقم المعياري الدولي للكتاب1932-6203
معرّف المصادر الموحدhttp://dx.doi.org/10.1371/journal.pone.0144401
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4293
الملخصObjective Adipose Tissue Stromal Cells (ASCs) have important clinical applications in the regenerative medicine, cell replacement and gene therapies. Subcutaneous Adipose Tissue (SAT) is the most common source of these cells. The adult human thymus degenerates into adipose tissue (TAT). However, it has never been studied before as a source of stem cells. Material and Methods We performed a comparative characterization of TAT-ASCs and SAT-ASCs from myocardial ischemic subjects (n = 32) according to the age of the subjects. Results TAT-ASCs and SAT-ASCs showed similar features regarding their adherence, morphology and in their capacity to form CFU-F. Moreover, they have the capacity to differentiate into osteocyte and adipocyte lineages; and they present a surface marker profile corresponding with stem cells derived from AT; CD73+CD90+CD105+CD14-CD19-CD45-HLA-DR. Interestingly, and in opposition to SAT-ASCs, TAT-ASCs have CD14+CD34+CD133+CD45- cells. Moreover, TAT-ASCs from elderly subjects showed higher adipogenic and osteogenic capacities compared to middle aged subjects, indicating that, rather than impairing; aging seems to increase adipogenic and osteogenic capacities of TAT-ASCs. Conclusions This study describes the human TAT as a source of mesenchymal stem cells, which may have an enormous potential for regenerative medicine.
راعي المشروعInstituto de Salud Carlos III/FEDER, EU (PI10/01947, PI13/02628), CTS-7895 from the Consejer?a de Econom?a e Innovaci?n, Ciencia y Empleo, Junta de Andaluc?a/FEDER, EU. R. El Bekay is supported by fellowships from the ISCIII/FEDER, EU "Miguel Servet II" (CPII13/00041). AV-R is under a contract Proyectos de I+D+i para j?venes investigadores from the Ministerio de Econom?a y Competitividad (SAF2014-60649-JIN) and co-funded by Fondo Europeo de Desarrollo Regional-FEDER.
اللغةen
الناشرPublic Library of Science
الموضوع5' nucleotidase
CD133 antigen
CD14 antigen
CD19 antigen
CD34 antigen
CD45 antigen
endoglin
HLA DR antigen
Thy 1 antigen
adipocyte
adipogenesis
adipose tissue
adipose tissue cell
adipose tissue stromal cell
bone development
cell adhesion
cell differentiation
cell structure
colony forming unit F
heart muscle ischemia
osteocyte
stroma cell
subcutaneous fat
thymus
thymus adipose tissue
العنوانMyocardial ischemic subject's thymus fat: A novel source of multipotent stromal cells
النوعArticle
رقم العدد12
رقم المجلد10
dc.accessType Open Access


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