Functional connectivity alterations in epilepsy from resting-state functional MRI
المؤلف | Rajpoot, Kashif |
المؤلف | Riaz, Atif |
المؤلف | Majeed, Waqas |
المؤلف | Rajpoot, Nasir |
تاريخ الإتاحة | 2016-03-31T14:00:57Z |
تاريخ النشر | 2015-08 |
اسم المنشور | PLoS ONE |
المصدر | Scopus |
الاقتباس | Rajpoot K, Riaz A, Majeed W, Rajpoot N (2015) Functional Connectivity Alterations in Epilepsy from Resting-State Functional MRI. PLoS ONE 10(8): e0134944. |
الرقم المعياري الدولي للكتاب | 1932-6203 |
الملخص | The study of functional brain connectivity alterations induced by neurological disorders and their analysis from resting state functional Magnetic Resonance Imaging (rfMRI) is generally considered to be a challenging task. The main challenge lies in determining and interpreting the large-scale connectivity of brain regions when studying neurological disorders such as epilepsy. We tackle this challenging task by studying the cortical region connectivity using a novel approach for clustering the rfMRI time series signals and by identifying discriminant functional connections using a novel difference statistic measure. The proposed approach is then used in conjunction with the difference statistic to conduct automatic classification experiments for epileptic and healthy subjects using the rfMRI data. Our results show that the proposed difference statistic measure has the potential to extract promising discriminant neuroimaging markers. The extracted neuroimaging markers yield 93.08% classification accuracy on unseen data as compared to 80.20% accuracy on the same dataset by a recent state-of-the-art algorithm. The results demonstrate that for epilepsy the proposed approach confirms known functional connectivity alterations between cortical regions, reveals some new connectivity alterations, suggests potential neuroimaging markers, and predicts epilepsy with high accuracy from rfMRI scans. |
اللغة | en |
الناشر | Public Library of Science |
الموضوع | brain function brain region controlled study default mode network diagnostic accuracy diagnostic test accuracy study dorsal attention network epilepsy focal epilepsy functional connectivity functional magnetic resonance imaging generalized epilepsy major clinical study neuroimaging nuclear magnetic resonance scanner prediction resting state functional magnetic resonance imaging resting state network sensitivity and specificity task performance temporal lobe epilepsy |
النوع | Article |
رقم العدد | 8 |
رقم المجلد | 10 |
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