تصفح College of Pharmacy حسب المؤلف "Gupta, Ishita"
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Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
Fouzat, Arij; Hussein, Ola Jihad; Gupta, Ishita; Al-Farsi, Halema F.; Khalil, Ashraf; Al Moustafa, Ala Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; Al Moustafa, Ala-Eddin; Al Farsi, Halema F... more authors ... less authors ( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ... -
Mesoporous silica coated carbon nanofibers reduce embryotoxicity via ERK and JNK pathways
Abdo, Ghada G.; Gupta, Ishita; Kheraldine, Hadeel; Rizeq, Balsam; Zagho, Moustafa M.; Khalil, Ashraf; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier Ltd , 2021 , Article)Carbon nanofibers (CNFs) have been implicated in biomedical applications, yet, they are still considered as a potential hazard. Conversely, mesoporous silica is a biocompatible compound that has been used in various ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
Rizeq, Balsam; Gupta, Ishita; Kheraldine, Hadeel; Elkhalifa, Dana; Al-Farsi, Halema F.; Moustafa, Ala-Eddin A.; Khalil, Ashraf... more authors ... less authors ( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ...