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Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
(
MDPI AG
, 2019 , Article)
Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ...
Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase
(
NLM (Medline)
, 2018 , Article)
Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator ...
Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region
(
Springer International Publishing
, 2017 , Article Review)
Background
Genetic polymorphisms are known to influence outcomes with phenytoin yet effects in the Middle East and North Africa region are poorly understood.
Objectives
The objective of this systematic review was to ...
Setting the agenda for clinical pharmacy in Qatar: thematic and content analyses of news media headlines
(
Centro de Investigaciones y Publicaciones Farmaceuticas
, 2019 , Article)
Public awareness of the role of pharmacists and availability of pharmacy services in Qatar is low. As per agenda-setting theory, mass media may be contributing toward this problem by selecting and disseminating headlines ...
The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance.
(
MDPI
, 2019 , Article Review)
Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ...
Development of injectable PEGylated liposome encapsulating disulfiram for colorectal cancer treatment
(
MDPI AG
, 2019 , Article)
Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but the application in clinics for anti-cancer therapy has been limited by its prompt metabolism. Conventional liposomes ...
A qualitative exploration of barriers to medication adherence among patients with uncontrolled diabetes in Qatar: integrating perspectives of patients and health care providers.
(
Dove Medical Press
, 2018 , Article)
To develop an in-depth understanding of the barriers to medication adherence among patients with uncontrolled diabetes attending primary health care (PHC) centers in Qatar by exploring and integrating patients' and health ...
Reporting and methodological quality of systematic reviews and meta-analysis with protocols in Diabetes Mellitus Type II: A systematic review.
(
Public Library of Science
, 2020 , Article)
Systematic reviews with or without meta-analyses (SR/MAs) are strongly encouraged to work from a protocol to facilitate high quality, transparent methodology. The completeness of reporting of a protocol (PRISMA-P) and ...
Pharmaceutical pricing policies in Qatar and Lebanon: narrative review and document analysis
(
Blackwell Publishing Ltd
, 2019 , Article Review)
Objectives: This study aimed at reviewing and analysing the pharmaceutical pricing policies implemented in two middle-east countries. Methods: Official documents related to national pharmaceutical pricing policies were ...
Healthcare professionals' perspectives on a mental health educational campaign for the public
(
SAGE Publications Ltd
, 2017 , Article)
Objective: To explore barriers and facilitators in implementing an educational campaign in mental health for the public in Qatar. Design: Qualitative study. Setting: Healthcare facilities across Qatar were used as the ...