Search
Now showing items 231-240 of 682
A Review of Clinical Pharmacokinetic and Pharmacodynamic Relationships and Clinical Implications for Drugs Used to Treat Multi-drug Resistant Tuberculosis
(
Springer
, 2020 , Article Review)
Multidrug-resistant tuberculosis (MDR-TB) is becoming a global health crisis. The World Health Organization has released new guidelines for the use of tuberculosis-active drugs for the treatment of patients with MDR-TB. ...
Practice implications of an antimicrobial stewardship intervention in a tertiary care teaching hospital, Qatar
(
World Health Organization
, 2019 , Article)
Background: Antibiotic misuse is a worldwide public health problem and has been associated with increased morbidity, length of hospital stay, mortality, healthcare costs, and most importantly antibiotic resistance. Aims: ...
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.
(
Dove Medical Press
, 2020 , Article)
Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma. However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic ...
Critical appraisal of tobacco dependence treatment guidelines
(
Springer
, 2020 , Article)
© 2020, The Author(s). Background Tobacco use is a leading preventable cause of morbidity and mortality globally. Clinical practice guidelines for the treatment of tobacco use dependence are of varied scope and quality, ...
An original transformer and switched-capacitor (T & SC)-based extension for DC-DC boost converter for high-voltage/low-current renewable energy applications: Hardware implementation of a new T & SC boost converter
(
MDPI AG
, 2018 , Article)
In this article a new Transformer and Switched Capacitor-based Boost Converter (T & SC-BC) is proposed for high-voltage/low-current renewable energy applications. The proposed T & SC-BC is an original extension for ...
Administration error of benzathine penicillin G in a Saudi male
(
Wiley-Blackwell
, 2019 , Article)
Background
Benzathine penicillin G is indicated for intramuscular (IM ) administration. There have been reports of unintentional intravenous (IV ) administration, which has been associated with cardiorespiratory arrest ...
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
(
Springer-Verlag France
, 2019 , Article)
Background
Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM ...
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting
(
Excerpta Medica Inc.
, 2019 , Article)
Purpose: Morphine and fentanyl opioids are common analgesic agents for consideration in the neonatal intensive care unit (NICU) for neonates with respiratory distress syndrome (RDS) and undergoing mechanical ventilation ...
Multimorbidity and emergency department visits by a homeless population: a database study in specialist general practice.
(
Royal College of General Practitioners
, 2019 , Article)
Estimating healthcare needs of the homeless is associated with challenges in identifying the eligible population. To explore the demographic characteristics, disease prevalence, multimorbidity, and emergency department ...
Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell Dysfunction Independently of Cell Survival.
(
Frontiers Media
, 2020 , Article)
Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly ...