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Mechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies
(
Elsevier
, 2021 , Article)
Protein misfolding and aggregation can be induced by a wide variety of factors, such as dominant disease-associated mutations, changes in the environmental conditions (pH, temperature, ionic strength, protein concentration, ...
Long-acting injectable antipsychotics: A systematic review of their non-systemic adverse effect profile
(
Dove Medical Press
, 2021 , Article)
Introduction: Long acting injectable (LAI) antipsychotics are commonly used in the treatment of schizophrenia to improve adherence and clinical outcomes. Concerns have been reported in relation to their non-systemic or ...
Genetic and non-genetic factors impact on inr normalization in preprocedural warfarin management
(
Dove Medical Press
, 2021 , Article)
Background: Annually, 10% of warfarin patients will likely need to stop warfarin prior to elective surgery to achieve a baseline international normalization ratio (INR) level (INR ≤ 1.2) at the time of the procedure. This ...
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M® membrane and excised human skin
(
Taylor and Francis Ltd.
, 2021 , Article)
Tocotrienol (TRF) ethosomes were developed and evaluated in vitro for potential transdermal delivery against melanoma. The optimised TRF ethosomal size ranged between 64.9 ± 2.2 nm to 79.6 ± 3.9 nm and zeta potential (ZP) ...
Soliciting the Oral Route as a Logical Approach to Managing Colon Cancer
(
Frontiers Media S.A.
, 2021 , Article)
According to Global Cancer Incidence, Mortality and Prevalence (GLOBOCAN) 2018, colon cancer (CC) is the third most common cancer in men and second in women worldwide (Bray et al., 2018). Approximately 1.8 million new colon ...
Lyophilized drug-loaded solid lipid nanoparticles formulated with beeswax and theobroma oil
(
MDPI AG
, 2021 , Article)
Solid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or ...
Pharmacokinetics and tissue distribution of an orally administered mucoadhesive chitosan-coated amphotericin B-Loaded nanostructured lipid carrier (NLC) in rats
(
Taylor and Francis Inc.
, 2020 , Article)
Oral delivery of amphotericin B (AmpB) is desirable because it provides a more patient-friendly mode of administration compared to the current delivery approach akin with the marketed AmpB formulations. The goal of the ...
The types and pattern of use of mobile health applications among the general population: A cross-sectional study from Selangor, Malaysia
(
Dove Medical Press
, 2021 , Article)
Purpose: The aims of this study are to explore the types and patterns of use of health mobile apps among pharmacy clients in Selangor, Malaysia, and to explore the users’ experiences and views regarding the benefits of and ...
COVID-19 vaccination: From interesting agent to the patient
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. ...
Genetic polymorphism effect on warfarin–rifampin interaction: A case report and review of literature
(
Dove Medical Press
, 2021 , Article)
Warfarin–rifampin interaction has been reported since the 1970s. Due to rifampin’s strong induction of CYP2C9, most cases could not attain the target international normalized ratio (INR) despite warfarin dose escalation. ...