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Population Pharmacokinetics of Intravenous Methotrexate in Patients with Hematological Malignancies: Utilization of Routine Clinical Monitoring Parameters
(
Springer-Verlag France
, 2017 , Article)
Background and Objective: Clinical response to methotrexate in cancer is variable and depends on several factors including serum drug exposure. This study aimed to develop a population pharmacokinetic model describing ...
Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region
(
Springer International Publishing
, 2017 , Article Review)
Background
Genetic polymorphisms are known to influence outcomes with phenytoin yet effects in the Middle East and North Africa region are poorly understood.
Objectives
The objective of this systematic review was to ...
Can source triangulation be used to overcome limitations of self-assessments? Assessing educational needs and professional competence of pharmacists practicing in qatar
(
John Wiley and Sons Inc.
, 2017 , Article)
Introduction: Continuing professional development activities should be designed to meet the identified personal goals of the learner. This article aims to explore the self-perceived competency levels and the professional ...
A systematic review of pharmaceutical pricing policies in developing countries
(
Blackwell Publishing Ltd
, 2017 , Article Review)
Objective
A systematic review was conducted to summarize government strategies aimed at controlling pharmaceutical prices in developing countries and their effects on relevant outcomes, and to qualitatively analyse eligible ...
A Systematic Scoping Review of the State of Pharmacovigilance and Governance in the MENA Region: Challenges and Opportunities
(
Springer International Publishing
, 2017 , Article Review)
Introduction
Pharmacovigilance (PV) systems around the world vary in capacity and maturity. Many factors can influence PV.
Objectives
This systematic scoping review aims to explore the opportunities for effective PV ...
Myocardial proteases and cardiac remodeling
(
Wiley-Liss Inc.
, 2017 , Article Review)
Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need ...
Perceptions of Yemeni physicians about interactions with medical representatives
(
Blackwell Publishing Ltd
, 2017 , Article)
Objective: Interaction between physicians and medical representatives (MR) is an area of controversy, which discussed heavily in the literature. However, the perspectives of physicians on the extent and composition of ...
Future perspectives on nonmedical prescribing
(
SAGE Publications Ltd
, 2017 , Article Review)
Many countries have implemented nonmedical prescribing (NMP) and many others are scoping prescribing practices with a view to developing NMP. This paper provides a future perspective on NMP in light of findings of an ...
Anticancer potential of sanguinarine for various human malignancies
(
Future Medicine Ltd.
, 2017 , Article Review)
Sanguinarine (Sang) - a benzophenanthridine alkaloid extracted from Sanguinaria canadensis - exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory activities on tumor cells of various cancer types as ...
Evaluation of the Effect of Moringa peregrina Extract on Learning and Memory: Role of Oxidative Stress
(
Springer New York LLC
, 2017 , Article)
Oxidative stress interferes with the functional roles of the hippocampus and results in cognitive decline. Antioxidant supplementation has a cognitive enhancing activity through protecting hippocampus brain cells from the ...