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Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
(
Wiley Periodicals, Inc
, 2017 , Article)
Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ...
Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro
(
Springer Netherlands
, 2017 , Article)
Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. Thus, there is an urgent need for ...
Nephroprotective Effects of Metformin in Diabetic Nephropathy
(
Wiley
, 2017 , Article)
Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ...
Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges.
(
Bentham Science Publishers
, 2017 , Article)
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which ...
Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury
(
Hindawi
, 2017 , Article)
Diabetic nephropathy (DN) is the leading cause of end stage renal disease worldwide. Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney. ...
Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
(
Hindawi
, 2017 , Article)
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ...
Stigma associated with mental illness: perspectives of university students in Qatar
(
Dove Press
, 2017 , Article)
Stigma in relation to mental illness is one of the main factors inhibiting people from seeking help. Studies have been undertaken looking into the knowledge, attitudes, and beliefs (KAB) about mental illness among residents ...
A Middle Eastern journey of integrating Interprofessional Education into the healthcare curriculum: a SWOC analysis
(
BioMed Central
, 2017 , Article)
Interprofessional education (IPE) is an emerging concept in the Middle East with a number of health professional degree programs continually striving to meet international accreditation requirements to enhance the quality ...
Effectiveness of a pharmacist-delivered smoking cessation program in the State of Qatar: a randomized controlled trial
(
BioMed Central
, 2017 , Article)
Background: Cigarette smoking is one of the major preventable causes of death and diseases in Qatar. The study objective was to test the effect of a structured smoking cessation program delivered by trained pharmacists on ...
Evaluation of the general public's knowledge, views and practices relating to appropriate antibiotic use in Qatar
(
Wiley-Blackwell Publishing Ltd
, 2017 , Article)
Objective: Studies completed internationally have demonstrated an alarming number of patients believed antibiotics are indicated in the treatment of viral infections and other self-limited illnesses. Evaluation of patient ...