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Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
(
MDPI
, 2021 , Article)
Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ...
A comprehensive review on the antiviral activities of chalcones
(
Taylor and Francis Ltd.
, 2021 , Article)
Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ...
Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles.
(
MDPI
, 2020 , Article)
The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N'-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic ...
Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers
(
Elsevier
, 2021 , Article)
Aerosolization is a non-invasive approach in drug delivery for localized and systemic effect. Nanostructured lipid carriers (NLCs) are new generation versatile carriers, which offer protection from degradation and enhance ...
Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone
(
Taylor and Francis Ltd.
, 2021 , Article)
The current study focuses on the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded lactobionic acid (LBA)-functionalized iron oxide magnetic ...
Impact of nanosizing on the formation and characteristics of polymethacrylate films: micro- versus nano-suspensions
(
Taylor and Francis Ltd.
, 2021 , Article)
Aqueous-based film coating suspensions are associated with reliance on alkalinising reagents and poor film formation. The impact of particle size in this process and resultant film properties remains unclear. This study ...
Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation
(
Pakistan Journal of Pharmaceutical Sciences
, 2021 , Article)
Piroxicam (PC) is a non-steroidal anti-inflammatory drug characterized by poor aqueous solubility and
reported to cause and impart crucial GIT irritation, bleeding, peptic and duodenal ulcer. Engineering of PC ...
Cyclodextrin diethyldithiocarbamate copper ii inclusion complexes: A promising chemotherapeutic delivery system against chemoresistant triple negative breast cancer cell lines
(
MDPI AG
, 2021 , Article)
Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion ...
Norfloxacin loaded lipid polymer hybrid nanoparticles for oral administration: Fabrication, characterization, in silico modelling and toxicity evaluation
(
MDPI
, 2021 , Article)
Norfloxacin (NOR), widely employed as an anti-bacterial drug, has poor oral bioavailability. Nano based drug delivery systems are widely used to overcome the existing oral bioavailability challenges. Lipid–Polymer Hybrid ...
Predicting factors of public awareness and perception about the quality, safety of drinking water, and pollution incidents
(
Springer
, 2021 , Article)
Public perception of drinking water quality and safety results from the interaction of multiple factors, including the public engagement, which requires sufficient knowledge and awareness. This issue has yet to be addressed ...