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Recent developments on (−)-colchicine derivatives: Synthesis and structure-activity relationship
(
Elsevier
, 2020 , Article Review)
(−)-Colchicine, an anti-microtubulin polymerization agent, is a valuable medication and the drug of choice for gout, Behçet’s disease and familial Mediterranean fever. It has a narrow therapeutic index due to its high ...
Intermittent levosimendan infusion in ambulatory patients with end-stage heart failure: a systematic review and meta-analysis of 984 patients
(
Springer
, 2021 , Article Review)
We sought to synthesize the available evidence regarding safety and efficacy of intermittent levosimendan (LEVO) infusions in ambulatory patients with end-stage heart failure (HF). Safety and efficacy of ambulatory ...
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled ...
Creation of an inventory of quality markers used to evaluate pharmacokinetic literature: A systematic review
(
Wiley
, 2021 , Article Review)
What is known and objective: Robust critical appraisal tools for clinical pharmacokinetic studies are limited. Before development of such a tool is possible, quality markers (items deemed important for credibility of study ...
Comparative efficacy of empagliflozin versus placebo in the treatment of type 1 diabetes mellitus: A meta-analysis of randomized controlled trials
(
Uniwersytet Medyczny w Lublinie
, 2021 , Article)
The objective of this meta-analysis study was to evaluate the comparative efficacy of empagliflozin (25 mg) with placebo in the treatment and management of type 1 diabetes mellitus. This study is a meta-analysis, so an ...
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
(2021 , Article)
Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols. Molecular diagnostics, ...
Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2020 , Article)
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions ...
Editorial : Rwanda Journal of Medicine and Health Sciences Vol.4 No.2
(
University of Rwanda College of Medicine and Health Sciences
, 2021 , Other)
The year 2020 has been a sad one for the EAC RCE-VIHSCM. Our esteemed colleague, former Training Coordinator, Associate Editor of the Rwanda Journal of Medicine and Health Sciences, and Chairman of Board at Rwanda Medical ...