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Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy
(
Public Library of Science
, 2015 , Article)
Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin ...
Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal S6 Kinase
(
Public Library of Science
, 2015 , Article)
Studies using pharmacological and genetic approaches have shown that increased activity/expression of the Na+/H+ exchanger isoform 1 (NHE1) play a critical role in the pathogenesis of cardiac hypertrophy. Despite the ...
The Efficacy of Etoposide on H9c2 Cardiomyoblasts Against Doxorubicin Induced Cardiotoxicity
(
OMICS International
, 2015 , Article)
Background: Doxorubicin (DOX), a widely used anticancer drug, has been associated with cardiotoxicity.
Recently, DOX-induced cardiotoxicity has been attributed to topoisomerase II (TOPII)-β expression and activity. In
our ...
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
(
Hindawi Publishing Corporation
, 2018 , Article)
Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ...
p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
(
BioMed Central
, 2016 , Article)
A global survey of cancer has shown that lung cancer is the most common cause of the new cancer cases and cancer deaths in men worldwide. The mortality from lung cancer is more than the combined mortality from breast, ...
Examination of Job Satisfaction, Achievements, and Employment Preparedness among College of Pharmacy Alumni: A Study From Qatar
(
Qatar University Press
, 2021 , Poster)
Background: Job satisfaction in healthcare is of special interest as has a direct relation with the quality of care provided to patients. It is affected by several factors including the nature of the work, level of educational ...
An Examination of the Employment Preparedness, Job Satisfaction, and Impact in the Workplace of Qatar University Pharmacy Alumni: A Mixed Methods Study
(
Qatar University Press
, 2021 , Poster)
Introduction: The level of alumni's job satisfaction and preparedness has been found to affect the impact in the workplace. Little is known about alumni's employment experience in Qatar. Objective: The aim of this study ...
Heme Oxygenase Isoform 1 Regresses Cardiomyocyte Hypertrophy Through Regressing Sodium Proton Exchanger Isoform 1 Activity
(
Hamad bin Khalifa University Press (HBKU Press)
, 2014 , Conference Paper)
Background: Pathological cardiac hypertrophy is a worldwide problem and an independent risk factor that predisposes the heart to failure. Enhanced activity or expression of the sodium proton exchanger isoform 1 (NHE1) has ...
Inhibition of p90 Ribosomal S6 Kinase Attenuates Cell Migration and Proliferation of the Human Lung Adenocarcinoma through Phospho-GSK-3b and Osteopontin
(
Hamad bin Khalifa University Press (HBKU Press)
, 2016 , Conference Paper)
Background
Lung cancer is the second most common cancer in both men and women and it is the leading cause of cancer deaths worldwide. Lung cancer can be divided into two broad categories: non-small cell lung cancer ...
Nanotechnology in medicine – our experiences
(
Macedonian Pharmaceutical Association
, 2022 , Article)
The success of design criteria for long-circulating drug delivery systems to support membrane receptor-ligand interaction and internalization has been limited and there is a need to develop smarter approaches for efficient ...