Three-dimensional phenotype characteristics of skeletal class III malocclusion in adult Chinese: a principal component analysis–based cluster analysis
المؤلف | Alshoaibi, Lina Hassan |
المؤلف | Alareqi, Mohammed Muneer |
المؤلف | Al-Somairi, Majedh Abdo Ali |
المؤلف | Al-Tayar, Barakat |
المؤلف | Almashraqi, Abeer A. |
المؤلف | An, Xiaoli |
المؤلف | Alhammadi, Maged Sultan |
تاريخ الإتاحة | 2023-06-19T09:39:34Z |
تاريخ النشر | 2023-05-01 |
اسم المنشور | Clinical Oral Investigations |
المعرّف | http://dx.doi.org/10.1007/s00784-023-05033-y |
الاقتباس | Alshoaibi, L. H., Alareqi, M. M., Al-Somairi, M. A. A., Al-Tayar, B., Almashraqi, A. A., An, X., & Alhammadi, M. S. (2023). Three-dimensional phenotype characteristics of skeletal class III malocclusion in adult Chinese: a principal component analysis–based cluster analysis. Clinical Oral Investigations, 1-17. |
الرقم المعياري الدولي للكتاب | 1432-6981 |
الملخص | Background: Skeletal class III malocclusion has a diverse and complicated aetiology involving environmental and genetic factors. It is critical to correctly classify and define this malocclusion to be diagnosed and treated on a clinically sound basis. Thus, this study aimed to provide reliable and detailed measurements in a large ethnically homogeneous sample of Chinese adults to generate an adequate phenotypic clustering model to identify and describe the skeletal variation present in skeletal class III malocclusion. Materials and methods: This is a retrospective cross-sectional study in which 500 pre-treatments cone-beam computed tomography (CBCT) scans of patients with skeletal class III malocclusion (250 males and 250 females) were selected following specific selection criteria. Seventy-six linear, angular, and ratios measurements were three-dimensionally analysed using InVivo 6.0.3 software. These measurements were categorised into 47 skeletal, 18 dentoalveolar, and 11 soft tissue variables. Multivariate reduction methods: principal component analyses and cluster analyses were used to present the most common phenotypic groupings of skeletal class III malocclusion in Han ethnic group of Chinese adults. Results: The principal component analysis revealed eight principal components accounted for 72.9% of the overall variation of the data produced from the seventy-six variables. The first four principal components accounted for 53.37% of the total variations. They explained the most variation in data and consisted mainly of anteroposterior and vertical skeletal relationships. The cluster analysis identified four phenotypes of skeletal class III malocclusion: C1, 34%; C2, 11.4%; C3, 26.4%; and C4, 28.2%. Conclusion: Based on three-dimensional analyses, four skeletal class III malocclusion distinct phenotypic variations were defined in a large sample of the adult Chinese population, showing the occurrence of phenotypic variation between identified clusters in the same ethnic group. These findings might serve as a foundation for accurate diagnosis and treatment planning of each cluster and future genetic studies to determine the causative gene(s) of each cluster. |
راعي المشروع | This work was supported by the project of the National Natural Science Foundation of Gansu Province, China (No. 20JR5RA264). |
اللغة | en |
الناشر | Springer Nature |
الموضوع | Class III malocclusion Cluster analysis (CA) Phenotype Principal component analysis (PCA) |
النوع | Article |
الصفحات | 1-17 |
ESSN | 1436-3771 |
الملفات في هذه التسجيلة
الملفات | الحجم | الصيغة | العرض |
---|---|---|---|
لا توجد ملفات لها صلة بهذه التسجيلة. |
هذه التسجيلة تظهر في المجموعات التالية
-
أبحاث طب الأسنان [285 items ]