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AuthorTamimi, Faleh
AuthorAshammakhi, Nureddin
AuthorMansour, Alaa
Available date2023-07-05T04:37:46Z
Publication Date2022-05-01
Publication NameJournal of Craniofacial Surgery
Identifierhttp://dx.doi.org/10.1097/SCS.0000000000008376
CitationTamimi, Faleh∗; Ashammakhi, Nureddin†,‡; Mansour, Alaa§. How Do Bone Allografts Regenerate Bone?. Journal of Craniofacial Surgery 33(3):p 729-730, May 2022. | DOI: 10.1097/SCS.0000000000008376
ISSN10492275
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131408222&origin=inward
URIhttp://hdl.handle.net/10576/44952
Abstractutogenous bone is universally considered as the gold standard for grafting procedures, although it presents many limitations such as donor-site morbidity, and postoperative complications such as pain and bleeding. Allogenic bone matrices are excellent alter- natives to autogenous bone grafts because they overcome many of the limitations. This is why they are widely used in the field of dentistry, orthopedics, and craniofacial surgery. Bone allografts are available as mineralized (freeze-dried bone allografts) and demineralized freeze-dried bone allografts and in certain proce dures they show comparable regenerative performance to autoge nous bone grafts, and are well integrated with the host tissues However, the fundamental reasons behind the clinical success of these materials remain unclear It has been observed that demineralized bone matrix could stimulate ectopic bone formationuponits implantationimmuscular tissues. This phenomenon, led to the assumption that specific molecules are responsible for inducing bone formation, later identified as "bone morphogenetic proteins. However recent research has put doubt into this notion. Several studies have shown that the concentration of bone morphogenetic proteins in natural bone grafts is in orders of magnitudes lower than those needed to stimulate new bone formation. Then, why these materials still work so well!
Languageen
PublisherLippincott Williams and Wilkins
SubjectAllografts
Bone and Bones
bone transplantation
TitleHow Do Bone Allografts Regenerate Bone?
TypeOther
Pagination729-730
Issue Number3
Volume Number33


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