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AuthorSharif, Elham
AuthorRizk, Nasser M.
Available date2016-10-02T10:47:54Z
Publication Date2015-05-07
Publication NameInternational Journal of Endocrinology
Identifierhttp://dx.doi.org/10.1155/2015/927805
CitationN. M. Rizk and E. Sharif, “Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women,” International Journal of Endocrinology, vol. 2015, Article ID 927805, 10 pages, 2015.
ISSN1687-8337 (print)
ISSN1687-8345 (online)
URIhttp://hdl.handle.net/10576/4805
AbstractLeptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R with 𝑝 values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin
SponsorQatar University Student Fund no. QUST-CAS-SPR-12/13-1.
Languageen
PublisherHindawi Publishing Corporation
SubjectLEPTIN
PCOS
TitleLeptin And Free Leptin Receptor Is Associated With Polycystic Ovary Syndrome In Young Women
TypeArticle
Pagination10
Volume Number2015


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