Browsing College of Health Sciences by Author "Khan, Abbas"
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Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
Suleman, Muhammad; Murshed, Abduh; Imran, Kashif; Khan, Abbas; Ali, Zafar; Albekairi, Norah A; Wei, Dong-Qing; Yassine, Hadi M; Crovella, Sergio... more authors ... less authors ( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Investigating the role of functional mutations in leucine binding to Sestrin2 in aging and age-associated degenerative pathologies using structural and molecular simulation approaches
Khan, Abbas; Zahid, Muhammad Ammar; Shahab, Muhammad; Al-Zoubi, Raed M.; Shkoor, Mohanad; Benameur, Tarek; Agouni, Abdelali... more authors ... less authors ( Taylor & Francis , 2024 , Article)Leucine is the native known ligand of Sestrin2 (Sesn2) and its interaction with Sesn2 is particularly important, as it influences the activity of mTOR in aging and its associated pathologies. It is important to find out ...