Browsing College of Health Sciences by Author "Fardoun, Manal M."
Now showing items 1-3 of 3
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Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction
Fardoun, Manal M.; Issa, Khodr; Maaliki, Dina; Nasser, Suzanne A.; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Elsevier , 2020 , Article)Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's ... -
Repurposing cilostazol for raynaud's phenomenon
El-Hachem, Nehme; Fardoun, Manal M.; Slika, Hasan; Baydoun, Elias; Eid, Ali H. ( Bentham Science Publishers , 2021 , Other)Raynaud's Phenomenon (RP) results from exaggerated cold-induced vasoconstriction. RP patients suffer from vasospastic attacks and compromised digital blood perfusion leading to a triple color change at the level the fingers. ... -
Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros
Mesmar, J.; Mesmar, Joelle; Fardoun, Manal M.; Abdallah, Rola; Al Dhaheri, Yusra; Yassine, Hadi M.; Iratni, Rabah; Badran, Adnan; Eid, Ali H.; Baydoun, Elias... more authors ... less authors ( MDPI AG , 2021 , Article)Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, ...