Browsing College of Health Sciences by Author "Rizk, Nasser"
Now showing items 1-18 of 18
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12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
Othman, Amira; Ahmad, Saif; Megyerdi, Sylvia; Mussell, Rene; Choksi, Karishma; Maddipati, Krishna Rao; Elmarakby, Ahmed; Rizk, Nasser; Al-Shabrawey, Mohamed... more authors ... less authors ( Public Library of Science , 2013 , Article)The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. FITC-dextran flux across the REC monolayers and electrical ... -
Adiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks
Bushra, Sumbul; Al-Sadeq, Duaa W.; Bari, Redwana; Sahara, Afifah; Fadel, Amina; Rizk, Nasser... more authors ... less authors ( dovepress , 2022 , Article)Background: The pathophysiology of diabetic retinopathy (DR) is multifaced. A low level of circulating adiponectin (APN) in type 2 diabetes is associated with microvasculature complications, and its role in the evolution ... -
Association between Genetic Variants of GC Gene at 4q13.3 and Vitamin D Concentrations in Adult Females
sharif, Elham; Rizk, Nasser; Thakur, Hajera; Kurdi, Tasnim; Alwakeel, Mariam ( Longdom , 2019 , Article)Background: Vitamin D binding protein, encoded by the GC gene (on 4q13.3), plays an important role in transporting vitamin D. Several Genome-Wide Association Studies (GWASs) have established a significant association ... -
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Al-Sharshani, Dalal; Velayutham, Dinesh; Samara, Muthanna; Gazal, Reham; Al Haj Zen, Ayman; Ismail, Mohamed A.; Ahmed, Mahmoud; Nasrallah, Gheyath; Younes, Salma; Rizk, Nasser; Hammuda, Sara; Qoronfleh, M. Walid; Farrell, Thomas; Zayed, Hatem; Abdulrouf, Palli Valapila; AlDweik, Manar; Silang, John Paul Ben; Rahhal, Alaa; Al-Jurf, Rana; Mahfouz, Ahmed; Salam, Amar; Al Rifai, Hilal; Al-Dewik, Nader I.... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Background: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Objective: The study aimed to investigate ... -
Associations of Vitamin D Receptor Polymorphisms with Coronary Artery Diseases
Sharif, Elham; Rizk, Nasser; Abu Aqel, Sirin; Masoud, Ofelia (2016 , Poster)Background: Previous studies have investigated the association of rs1544410, rs7975232 and rs731236 polymorphisms on vitamin D receptor gene and its impact on diseases such as cancer, diabetes and hypertension in different ... -
Effect of CYP2C19 genetic variants on bleeding and major adverse cardiovascular events in a cohort of Arab patients undergoing percutaneous coronary intervention and stent implantation
Ali, Zainab Omer; Bader, Loulia; Mohammed, Shaaban; Arafa, Salaheddin; Arabi, Abdulrahman; Cavallari, Larisa; Langaee, Taimour; Mraiche, Fatima; Rizk, Nasser; Awaisu, Ahmed; Shahin, Mohamed H.; Elewa, Hazem... more authors ... less authors ( Lippincott Williams and Wilkins , 2022 , Article)Introduction One-third of patients have clopidogrel resistance that may lead to major adverse cardiac events (MACEs). By contrast, it was found that some clopidogrel-treated patients have hyperresponsive platelets that are ... -
Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells
Alheidous, Sara; Al-Muraikhy, Shamma; Rizk, Nasser; Sellami, Maha; Donati, Francesco; Botre, Francesco; Al-Mansoori, Layla; Elrayess, Mohamed A.... more authors ... less authors ( Frontiers Media , 2022 , Article)Introduction: The immunomodulatory effect of physical activity can impact insulin signaling differentially in adipose tissues and skeletal muscle cells, depending on sport intensity. In this study, the effect of serum from ... -
The frequency of polycystic ovary syndrome in young reproductive females in Qatar
Sharif, Elham; Rahman, Sumaya; Zia, Yumna; Rizk, Nasser ( Dove Medical Press , 2016 , Article)This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, ... -
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
Ibrahim, Ahmed S.; Elshafey, Sally; Sellak, Hassan; Hussein, Khaled A.; El-Sherbiny, Mohamed; Abdelsaid, Mohammed; Rizk, Nasser; Beasley, Selina; Tawfik, Amany M.; Smith, Sylvia B.; Al-Shabrawey, Mohamed... more authors ... less authors ( American Society for Biochemistry and Molecular Biology , 2015 , Article)Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ... -
Lipidomics for the Prediction of the Unstable Coronary Plaque
Jacob, Shana Sunny; Rizk, Nasser; Singh, Rajvir; Al Suwaidi, Jassim; Yacoub, Magdi ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Plaques that build up in the lining of the coronary arteries are made up of lipids, inflammatory cells, smooth muscle cells and connective tissue. Thormbosis of a not necessarily occlusive but unstable plaque most often ... -
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
Mehta, Khyati Y.; Wu, Hung-Jen; Menon, Smrithi S.; Fallah, Yassi; Zhong, Xiaogang; Rizk, Nasser; Unger, Keith; Mapstone, Mark; Fiandaca, Massimo S.; Federoff, Howard J.; Cheema, Amrita K.... more authors ... less authors ( Impact Journals , 2017 , Article)Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is no blood test for early detection and diagnosis of this disease. Several research groups have reported on metabolomics based ... -
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
Ibrahim, Ahmed S.; Tawfik, Amany M.; Hussein, Khaled A.; Elshafey, Sally; Markand, Shanu; Rizk, Nasser; Duh, Elia J.; Smith, Sylvia B.; Al-Shabrawey, Mohamed... more authors ... less authors ( Elsevier , 2015 , Article)We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal ... -
Postprandial insulin and triglyceride concentrations are suppressed in response to breaking up prolonged sitting in Qatari females
Chrismas, Bryna C.R.; Taylor, Lee; Cherif, Anissa; Sayegh, Suzan; Rizk, Nasser; El-Gamal, Abdelrahman; Allenjawi, Salwa Hassan; Bailey, Daniel P.... more authors ... less authors ( Frontiers Media S.A. , 2019 , Article)Background: Cultural, environmental and logistical factors challenge the Qatari population, particularly females, to engage in physical activity, and there is a high prevalence of diabetes in this population. Sedentary ... -
The prevalence of vitamin D deficiency among female college students at Qatar University
Sharif, Elham A.; Rizk, Nasser ( Medical Services Department Saudi Arabian Armed , 2011 , Article)Nowadays vitamin D deficiency is considered as a common problem among many Arab countries including Lebanon, Qatar, Saudi Arabia, UAE and other European countries as documented by many studies (1,2,3,5). Vitamin D is a ... -
The Relationship Between Leptin and PCOS
Sharif, Elham; Faisal, Amal; Osman, Amal; Rizk, Nasser ( De Gruyter , 2014 , Conference Paper)Background: The ob gene produces a leptin hormone that works as a satiety signal to the hypothalamus. Leptin may have a role in polycystic ovary syndrome (PCOS) via its role on obesity and insulin resistance. Materials ... -
Retinopathy of Type 1 Diabetes in Arab Countries: Systematic Review and Meta-Analysis.
Zayed, Hatem; Abdel Motal, Ussama M; Gopalakrishnan, Akila; Ponnuraja, Chinnayan; Doss, C George Priya; Rizk, Nasser; Shebl, Fatma M... more authors ... less authors ( Karger , 2018 , Article Review)To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. We systematically searched 4 different literature databases (PubMed, Science Direct, ... -
The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies
Kassab, Amal; Rizk, Nasser; Prakash, Satya ( MDPI , 2022 , Article Review)Advances in aging studies brought about by heterochronic parabiosis suggest that aging might be a reversable process that is affected by changes in the systemic milieu of organs and cells. Given the broadness of such a ... -
Sulforaphane Downregulates Hepatic Fibroblast Growth Factor 21 (FGF21) of Diet Induced Obese Mice
Rizk, Nasser; Noureldin, Arwa; Galal, Aya; Mohamed, Omnia; ElGamal, Abdelrahman; Elsayegh, Dina... more authors ... less authors ( The Obesity Society , 2020 , Conference Paper)Background: Fibroblast growth factor 21 is a hormone-like protein that plays a critical role as an energy regulator. Sulforaphane (SFN) is expected to have potential therapeutic effects in treating obesity. This study aims ...