Browsing College of Health Sciences by Title
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Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs
( Nature Publishing Group , 2019 , Article)The set of 55 ancestry informative SNPs (AISNPs) originally developed by the Kidd Lab has been studied on a large number of populations and continues to be applied to new population samples. The existing reference database ... -
Genetic Susceptibility to Arrhythmia Phenotypes in a Middle Eastern Cohort of 14,259 Whole-Genome Sequenced Individuals
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: The current study explores the genetic underpinnings of cardiac arrhythmia phenotypes within Middle Eastern populations, which are under-represented in genomic medicine research. Methods: Whole-genome sequencing ... -
Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review.
( Lippincott, Williams & Wilkins , 2021 , Article)Alzheimer disease (AD) is a progressive and complex neurodegenerative disease. Approximately 70% of AD risk is attributed to genetic risk factors, including variants in amyloid precursor protein (APP), presenilin 1 (PSEN1), ... -
Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Characterising genomic variants is paramount in understanding the pathogenesis and heterogeneity of normal-karyotype acute myeloid leukaemia (AML-NK). In this study, clinically significant genomic biomarkers were ascertained ... -
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
( Springer , 2024 , Article)Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analyze gene ... -
Genotype-phenotype correlation in 18 Egyptian patients with glutaric acidemia type I
( Springer US , 2017 , Article)Glutaric acidemia I (GAI) is an autosomal recessive metabolic disease caused by a deficiency of glutaryl-CoA dehydrogenase enzyme (GCDH). Patients with GAI are characterized by macrocephaly, acute encephalitis-like crises, ... -
Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
( Oxford University Press (OUP) , 2017 , Article)Isovaleric acidaemia (IVA) is an autosomal recessive inborn error of leucine metabolism. It is caused by a deficiency in the mitochondrial isovaleryl-CoA dehydrogenase (IVD) enzyme. In this study, we investigated eight ... -
Geographic, gender and seasonal variation of diabetes: a nationwide study among 1.4 million participants.
( Oxford University Press , 2021 , Other)China experienced a rapid increase in the prevalence of diabetes. To assess the prevalence of diabetes among Chinese adults who attend preventive physical examination, and analyzed geographical and gender difference in ... -
Geographical outcome disparities in infection occurrence after colorectal surgery: An analysis of 58,096 colorectal surgical procedures
( Elsevier Ltd , 2017 , Article)Background Despite improved surgical practices and in-hospital surveillance systems, surgical site infections remain a major public health problem worldwide and often require readmission to hospital. The aim was to apply ... -
Global epidemiology of Neisseria gonorrhoeae in infertile populations: Systematic review, meta-analysis and metaregression
( BMJ Journals , 2021 , Article)Objective To provide an in-depth systematic assessment of the global epidemiology of gonorrhoea infection in infertile populations. Methods A systematic literature review was conducted up to 29 April 2019 on international ... -
Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis
( BMC , 2020 , Article)Background: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a ... -
Global prevalence and incidence of pressure injuries in hospitalised adult patients: A systematic review and meta-analysis
( Elsevier , 2020 , Article)BackgroundPressure injuries are frequently occurred adverse events in hospitals, affecting the well-being of patients and causing considerable financial burden to healthcare systems. However, the estimates of prevalence, ... -
Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: A systematic analysis for the Global Burden of Disease Study 2017
( Elsevier B.V. , 2018 , Article)Background Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of ... -
Global, regional, and national consumption of animal-source foods between 1990 and 2018: findings from the Global Dietary Database
( Elsevier , 2022 , Article)Background: Diet is a major modifiable risk factor for human health and overall consumption patterns affect planetary health. We aimed to quantify global, regional, and national consumption levels of animal-source foods ... -
Glucose- and triglyceride-lowering dietary penta-O-galloyl-α-D-glucose reduces expression of PPARγ and C/EBPα, induces p21-Mediated G1 phase cell cycle arrest, and inhibits adipogenesis in 3T3-L1 preadipocytes
( Thieme , 2015 , Article)Plant polyphenols, such as hydrolysable tannins, are present in the human diet and known to exhibit anti-diabetic and anti-obesity activity. We previously reported that the representative hydrolysable tannin compound ... -
Glycemic index of selected carbohydrate-based foods consumed in Qatar
( Taylor & Francis , 2010 , Article)This study determined the glycemic index (GI) of selected carbohydrate-rich foods consumed in Qatar. Recruited volunteers (n = 19) consumed two reference foods, glucose and white bread, and 10 test foods. The foods tested ... -
Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia
( Public Library of Science (USA) , 2016 , Article)Sideroblastic anemias are acquired or inherited anemias that result in a decreased ability to synthesize hemoglobin in red blood cells and result in the presence of iron deposits in the mitochondria of red blood cell ... -
Green synthesis of copper nanoparticles from Nigella sativa seed extract and evaluation of their antibacterial and antiobesity activity
( Wiley-Blackwell , 2023 , Article)In this study, the copper nanoparticles were synthesized using various concentrations (5%, 6 %, 8%, and 10%) of Nigella sativa seed extracts, and their antibacterial and antiobesity effect was evaluated. The optimum particle ... -
Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity
( Elsevier , 2017 , Article)Abstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would ... -
"green" ZnO-Interlinked Chitosan Nanoparticles for the Efficient Inhibition of Sulfate-Reducing Bacteria in Inject Seawater
( American Chemical Society , 2018 , Article)Antimicrobial agents and corrosion inhibitors are widely used as biocides in the oil and gas industry to disinfect water and inhibit excessive biofilm formation caused mainly by sulfate reducing bacteria (SRBs). However, ...