Browsing College of Health Sciences by Subject "Molecular dynamics simulations"

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Chapter Four Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach

N., Madhana Priya; Balasundaram, Ambritha; Sidharth Kumar, N.; Udhaya Kumar, S.; Thirumal Kumar, D.; Magesh, R.; Zayed, Hatem; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2023 , Book chapter)
Cyclin-dependent kinase 6 (CDK6) is an essential kinase in cell cycle progression, which is a viable target for inhibitors in various malignancies, including breast cancer. This study aimed to virtually screen efficient ...
A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase

Thirumal Kumar, D; Mendonca, Enid; Priyadharshini Christy, J; George Priya Doss, C; Zayed, Hatem ( Elsevier , 2019 , Article)
DNA repair mechanism is a process through which the cell repairs its damaged DNA. Although there are several mechanisms involved in the DNA repair mechanisms, the direct reversal method is the simplest and does not require ...