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Krabbe Disease in the Arab World
(
IOS Press
, 2015 , Article)
The autosomal recessive inherited Krabbe disease (KD) is a devastating pediatric lysosomal storage disorder affecting white matter of the brain. It is caused by mutations in the gene coding for the lysosomal enzyme ...
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
(
American Society for Biochemistry and Molecular Biology
, 2015 , Article)
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ...
Unique associations of the Job Demand-Control-Support model subscales with leisure-time physical activity and dietary energy intake
(
National Institute of Occupational Safety and Health
, 2018 , Article)
Leisure-time physical activity (LTPA) and dietary energy intake are two important health behaviours, which at too low or high levels respectively, are associated with overweight and obesity. This study explores associations ...
Production and Determination of Bioavailable Iron in Sorghum and White bean Noodles
(
Enviro Research
, 2014 , Article)
The objective of this study was to find innovative approaches for the production of iron
fortified noodles that are natural and economically feasible. The functional food was produced
using different combinations . The ...
Recent advances in functional nanostructures as cancer photothermal therapy.
(
Dove Medical Press
, 2018 , Article Review)
Being a non-invasive and relatively safe technique, photothermal therapy has attracted a lot of interest in the cancer treatment field. Recently, nanostructure technology has entered the forefront of cancer therapy owing ...
The march of pluripotent stem cells in cardiovascular regenerative medicine.
(
BMC
, 2018 , Article Review)
Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a ...
Initial psychometric testing and validation of the Patient Participation in Pressure Injury Prevention scale
(
Wiley
, 2017 , Article)
AIMS:
The aim of this study was to develop the Patient Participation in Pressure Injury Prevention (PPPIP) scale and undertake initial testing of some of its psychometric properties.
BACKGROUND:
Clinical practice ...
Pharmacotherapy of Persons with Dementia in Long-Term Care in Australia: A Descriptive Audit of Central Nervous System Medications
(
Bentham Science Publishers
, 2017 , Article)
BACKGROUND:
Neuropsychiatric symptoms of dementia are often treated through the prescription of one or more psychotropic medications. However, limited efficacy and potential harmful side-effects has resulted in efforts ...
Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells
(
Elsevier
, 2017 , Article)
Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on ...
Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy
(
Elsevier
, 2017 , Article)
Abstract We designed a delivery system to obtain an efficient and optimal nose-to-brain transport of BACE1 siRNA, potentially useful in the treatment of Alzheimer's disease. We selected a cell-penetrating peptide, the short ...