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Taxane formulations: From plant to clinic
(
Springer International Publishing
, 2017 , Book chapter)
Taxanes including paclitaxel and docetaxel are highly active against many types of cancers. The main obstacle with developing delivery systems of taxanes is their poor water solubility. In this chapter, taxanes were reviewed ...
Association of low serum magnesium with diabetes and hypertension: findings from Qatar Biobank Study.
(
Elsevier
, 2019 , Article)
We aimed to examine the association between serum magnesium and diabetes and hypertension among Qatari adults. In the cross-sectional study, we used data from 9693 Qatari participants) aged 20 years and above attending the ...
Epstein-Barr virus-associated malignancies: Roles of viral oncoproteins in carcinogenesis
(
Frontiers Media S.A.
, 2018 , Article Review)
The Epstein-Barr virus (EBV) is the first herpesvirus identified to be associated with human cancers known to infect the majority of the world population. EBV-associated malignancies are associated with a latent form of ...
Cardiac rehabilitation delivery in low/middle-income countries
(
BMJ Publishing Group
, 2019 , Article)
Objective Cardiac rehabilitation (CR) availability, programme characteristics and barriers are not well-known in low/middle-income countries (LMICs). In this study, they were compared with high-income countries (HICs) and ...
Flavonoids in hypertension: a brief review of the underlying mechanisms.
(
Elsevier
, 2019 , Article)
Flavonoids are a diverse group of bioactive polyphenolic compounds abundant in dietary plants and herbs. Regular consumption of flavonoids exerts cardio-vasculoprotective effects and may reduce the onset or progression of ...
Clinical, biochemical, neuroradiological and molecular characterization of Egyptian patients with glutaric acidemia type 1.
(
Springer
, 2019 , Article)
Glutaric acidemia type 1 (GA1) is an inherited metabolic autosomal recessive disorder that is caused by a deficiency in glutaryl-CoA dehydrogenase (GCDH). Untreated patients suffer primarily from severe striatal damage. ...
An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD and Disulfiram.
(
Wiley
, 2019 , Article)
Alcohol use disorder (AUD) is a multifactorial psychiatric behavior disorder. Disulfiram is the first approved drug by the Food and Drug Administration for alcohol-dependent patients, which targets the ALDH2 enzyme. Several ...
Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish
(
Wiley
, 2019 , Article)
Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ...
Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction
(
Portland Press Ltd
, 2018 , Article)
The most common inherited cardiac disorder, hypertrophic cardiomyopathy (HCM), is characterized by thickening of heart muscle, for which genetic mutations in cardiac myosin-binding protein C3 (c-MYBPC3) gene, is the leading ...
Pressure injury prevalence and predictors among older adults in the first 36-hours of hospitalisation.
(
Wiley
, 2019 , Article)
To describe the prevalence and predictors of pressure injuries among older adults with limited mobility, within the first 36-hours of their hospital admission in Australia. Pressure injuries are significant health, safety ...