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Now showing items 181-190 of 258
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells
(
Elsevier
, 2016 , Article)
Abstract BackgroundMethylglyoxal (MGO) is known to be a major precursor of advanced glycation end products (AGEs) which are linked to diabetes and its related complications. Naturally occurring bioactive compounds could ...
Tea flavanols block advanced glycation of lens crystallins induced by dehydroascorbic acid
(
American Chemical Society
, 2015 , Article)
Growing evidence has shown that ascorbic acid (ASA) can contribute to protein glycation and the formation of
advanced glycation end products (AGEs), especially in the lens. The mechanism by which ascorbic acid can cause ...
Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ).
(
Elsevier
, 2019 , Book chapter)
Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations ...
Leadership in physiotherapy: Experiences of leaders of physiotherapy professional organisations
(
BMJ Publishing Group
, 2019 , Article)
Background The changing demands of healthcare and ongoing advances in practice and technology require corresponding change and development of the physiotherapy profession. Physiotherapy professional organisations perform ...
A computational method to characterize the missense mutations in the catalytic domain of GAA protein causing Pompe disease.
(
Wiley
, 2019 , Article)
Pompe disease is an autosomal recessive lysosomal storage disease caused by acid α-glucosidase (GAA) deficiency, resulting in intralysosomal accumulation of glycogen, including cardiac, skeletal, and smooth muscle cells. ...
Viability of and Escherichia coli O157:H7 and Listeria monocytogenes in a delicatessen appetizer (yogurt-based) salad as affected by citrus extract (Citrox©) and storage temperature
(
Academic Press
, 2018 , Article)
The antimicrobial effect of citrus extract (at 1 mL/kg [C1] and 2 mL/kg [C2]) on naturally occurring microbiota and inoculated pathogens (E. coli O157:H7 and L. monocytogenes at ca. 6 log cfu/g) in the traditional Greek ...
Cardiac rehabilitation delivery in Africa
(
Clinics Cardive
, 2019 , Article)
As of 2011, the leading cause of premature mortality in Africa is non-communicable rather than communicable disease (HIV/AIDS, tuberculosis). The burden of non-communicable
diseases (NCDs), and cardiovascular disease (CVD) ...
Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs
(
Mosby Inc.
, 2019 , Article)
The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence ...
Taxane formulations: From plant to clinic
(
Springer International Publishing
, 2017 , Book chapter)
Taxanes including paclitaxel and docetaxel are highly active against many types of cancers. The main obstacle with developing delivery systems of taxanes is their poor water solubility. In this chapter, taxanes were reviewed ...
Cardiovascular disease in the Eastern Mediterranean region: epidemiology and risk factor burden
(
Nature Publishing Group
, 2017 , Article Review)
The Eastern Mediterranean region (EMR) comprises 22 countries or territories spanning from Morocco in the west to Pakistan in the east, and contains a population of almost 600 million people. Like many other developing ...