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Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach.
(
MDPI
, 2020 , Article)
Filamins (FLN) are a family of actin-binding proteins involved in regulating the cytoskeleton and signaling phenomenon by developing a network with F-actin and FLN-binding partners. The FLN family comprises three conserved ...
Distinct antibody repertoires against endemic human coronaviruses in children and adults.
(
American Society for Clinical Investigation
, 2021 , Article)
Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory infection in humans. B cell responses to these "common cold" viruses remain incompletely understood. Here we report a comprehensive ...
Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar
(
Elsevier
, 2020 , Article)
ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors ...
The spectrum of beta-thalassemia mutations in the 22 Arab countries: a systematic review
(
Expert Reviews (formerly Future Drugs) / Taylor and Francis
, 2020 , Article)
To investigate the mutational spectrum in gene in Arab patients with Beta-Thalassemia (β-thal). Authors searched five databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar) from the time of inception ...
A novel homozygous TPM1 mutation in familial pediatric hypertrophic cardiomyopathy and in silico screening of potential targeting drugs.
(
Verduci Editore s.r.l.
, 2020 , Article)
Familial hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease. While sarcomeric gene mutations explain many HCM cases, the genetic basis of about half of HCM cases remains elusive. Here we aimed to ...
Thymoquinone, as a Novel Therapeutic Candidate of Cancers
(
MDPI
, 2021 , Article)
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for anticancer
properties is thymoquinone (TQ). As ...
Age and gender specific cut-off points for body fat parameters among adults in Qatar
(
BMC
, 2020 , Article)
© 2020 The Author(s). Background: Excessive body fat is the leading cause of many metabolic disorders. Therefore, assessing levels of body fat associated with risk of disease in specific populations is crucial. The present ...
Testing a multicomponent lifestyle intervention for combatting childhood obesity
(
BMC
, 2021 , Article)
Background: Childhood obesity is a major global health concern. Weight-management camps involving delivery of a program of physical activity, health education, and healthy eating are an effective treatment, although ...
Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis
(
Elsevier
, 2021 , Article)
ObjectivesCytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our objective was to perform a living systematic ...
Efficacy of a 3-day pre-travel schedule of Tafenoquine for malaria chemoprophylaxis: A network meta-analysis.
(
Oxford University Press
, 2021 , Article)
Chemoprophylaxis with weekly doses of tafenoquine (200 mg/day for 3 days before departure [loading dose], 200 mg/week during travel and one-week post-travel [maintenance doses]) is effective in preventing malaria. Effectiveness ...