Browsing Biomedical Sciences by Title
Now showing items 268-287 of 631
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Genetic polymorphisms associated with type 2 diabetes in the Arab world: A systematic review and meta-analysis.
( Elsevier , 2019 , Article)T2DM reach epidemic levels in the Arab countries. In this study, we aimed to perform a systematic review and meta-analysis to underline the susceptibility genetic profile of Arab patients with T2DM that result from SNPs. ... -
Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs
( Nature Publishing Group , 2019 , Article)The set of 55 ancestry informative SNPs (AISNPs) originally developed by the Kidd Lab has been studied on a large number of populations and continues to be applied to new population samples. The existing reference database ... -
Genetic Variants Associated With Alzheimer Disease in the 22 Arab Countries: A Systematic Review.
( Lippincott, Williams & Wilkins , 2021 , Article)Alzheimer disease (AD) is a progressive and complex neurodegenerative disease. Approximately 70% of AD risk is attributed to genetic risk factors, including variants in amyloid precursor protein (APP), presenilin 1 (PSEN1), ... -
Genomic Alterations, Gene Expression Profiles and Functional Enrichment of Normal-Karyotype Acute Myeloid Leukaemia Based on Targeted Next-Generation Sequencing
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Characterising genomic variants is paramount in understanding the pathogenesis and heterogeneity of normal-karyotype acute myeloid leukaemia (AML-NK). In this study, clinically significant genomic biomarkers were ascertained ... -
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
( Springer , 2024 , Article)Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analyze gene ... -
Genotype-phenotype correlation in 18 Egyptian patients with glutaric acidemia type I
( Springer US , 2017 , Article)Glutaric acidemia I (GAI) is an autosomal recessive metabolic disease caused by a deficiency of glutaryl-CoA dehydrogenase enzyme (GCDH). Patients with GAI are characterized by macrocephaly, acute encephalitis-like crises, ... -
Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
( Oxford University Press (OUP) , 2017 , Article)Isovaleric acidaemia (IVA) is an autosomal recessive inborn error of leucine metabolism. It is caused by a deficiency in the mitochondrial isovaleryl-CoA dehydrogenase (IVD) enzyme. In this study, we investigated eight ... -
"green" ZnO-Interlinked Chitosan Nanoparticles for the Efficient Inhibition of Sulfate-Reducing Bacteria in Inject Seawater
( American Chemical Society , 2018 , Article)Antimicrobial agents and corrosion inhibitors are widely used as biocides in the oil and gas industry to disinfect water and inhibit excessive biofilm formation caused mainly by sulfate reducing bacteria (SRBs). However, ... -
Gut microbial communities modulating brain development and function
( Taylor & Francis , 2012 , Article)Mammalian brain development is initiated in utero and internal and external environmental signals can affect this process all the way until adulthood. Recent observations suggest that one such external cue is the indigenous ... -
Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature
( Elsevier , 2023 , Article Review)Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and Helicobacter ... -
Helminth infections among long-term residents and settled immigrants in Qatar in the decade from 2005 to 2014: temporal trends and varying prevalence among subjects from different regional origins
( BioMed Central , 2016 , Article)Background: Travel and migration from developing regions, where tropical diseases are common, to more developed industrialised nations can contribute to the introduction and subsequent spread of infections. With its rapidly ... -
Helminth Infections Among Long-Term-Residents and Settled Immigrants in Qatar in the Decade from 2005 to 2014: Temporal Trends and Varying Prevalence Among Subjects from Different Regional Origins
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)We analysed the prevalence of helminth infection in a dataset of 31,008 records of subjects referred for stool examination at the Hamad Medical Corporation over the course of a decade (2005 to 2014, inclusive). Overall ... -
Hemoglobin Oxidation in Stored Blood Accelerates Hemolysis and Oxidative Injury to Red Blood Cells.
( Thieme Gruppe , 2020 , Article)Maintaining blood supply is a challenge in blood banks. Red blood cells (RBCs) stored at 4°C experience issues of biochemical changes due to metabolism of cells, leading to changes collectively referred to as "storage ... -
Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update
( MDPI , 2019 , Article)Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention ... -
Hepatitis E Viruses : Emerging and Transboundary Animal Viruses
( Springer , 2020 , Book chapter)Hepatitis E virus (HEV), member of genus Orthohepevirus in the family Hepeviridae, is the leading cause of hepatitis E. More than 20 million cases of hepatitis E virus (HEV) infection have been reported globally, out of ... -
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety
( Frontiers Media S.A. , 2020 , Article)Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing prevalence. They remain the leading causes of morbidity and mortality worldwide. The use of medicinal herbs continues to be an ... -
Herbal medicine for slowing aging and aging-associated conditions: Efficacy, mechanisms and safety
( Bentham , 2020 , Article)Aging and aging-associated diseases are issues with unsatisfactory answers in the medical field. Aging causes important physical changes which, even in the absence of the usual risk factors, render the cardiovascular system ... -
Herpes Simplex Virus Type 2 Seroprevalence Among Different National Populations of Middle East and North African Men
( Lippincott, Williams & Wilkins , 2018 , Article)BACKGROUND: There are limited data on herpes simplex virus type 2 (HSV-2) seroprevalence in the Middle East and North Africa (MENA). We examined country- and age-specific HSV-2 seroprevalence among select MENA populations ... -
High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow immunoassay (LFIA)
( Elsevier , 2023 , Article)BackgroundIn the last decade, point of care testing (POCT) such as lateral flow immunoassays (LFIA) were developed for rapid TSH measurement. Most of these TSH-LFIAs are designed for qualitative measurements (i.e., if TSH ... -
History of primary-series and booster vaccination and protection against Omicron reinfection
( American Association for the Advancement of Science , 2023 , Article)Laboratory evidence suggests a possibility of immune imprinting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the differences in the incidence of SARS-CoV-2 reinfection in a ...