Now showing items 64-83 of 631

    • Biological applications of imiquimod analogues: An update (Review) 

      Obeid, Joelle; Shaito, Abdullah; Hajj, Hiba El; Deleuze-Masquefa, Carine; Bonnet, Pierre Antoine; ... more authors ( Spandidos Publications , 2023 , Article Review)
      The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ...
    • Biological Performance of Primary Dental Pulp Stem Cells Treated with Gold Nanoparticles 

      Abuarqoub, Duaa; Mahmoud, Nouf; Alshaer, Walhan; Mohammad, Marwa; Ibrahim, Abed Alqader; ... more authors ( MDPI , 2023 , Article)
      Gold nanoparticles (AuNPs) are one of the most stable nanoparticles that have been prevalently used as examples for biological and biomedical applications. Herein, we evaluate the effect of AuNPs on the biological processes ...
    • Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences 

      Hoteit, R.; Hoteit, Reem; Yassine, Hadi M. ( MDPI , 2022 , Article Review)
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million ...
    • Biomaterials in Traumatic Brain Injury: Perspectives and Challenges 

      Aqel, Sarah; Al-Thani, Najlaa; Haider, Mohammad Z.; Abdelhady, Samar; Al Thani, Asmaa A.; ... more authors ( MDPI , 2023 , Article Review)
      Traumatic brain injury (TBI) is a leading cause of mortality and long-term impairment globally. TBI has a dynamic pathology, encompassing a variety of metabolic and molecular events that occur in two phases: primary and ...
    • Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections 

      Chemaitelly, Hiam; Ayoub, Houssein H.; AlMukdad, Sawsan; Faust, Jeremy S.; Tang, Patrick; ... more authors (2023 , Article)
      In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ...
    • Bladder neoplasms and NF-κB: an unfathomed association. 

      Jebaraj Walter, Charles Emmanuel; Durairajan, Sankari; Periyandavan, Kalaiselvi; Priya Doss C, George; Davis G, Dicky John; ... more authors ( Taylor & Francis , 2020 , Article)
      Bladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are ...
    • Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality 

      Shibeeb, Sapha; Abdallah, Atiyeh; Shi, Zumin ( Springer Nature , 2024 , Article)
      Lead is a heavy, toxic metal and its exposure to humans can lead to increased risk of cardiovascular disease development and mortality. Lead exposure has been shown to induce hyperhomocysteinemia (HHCy) which may be a major ...
    • BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar. 

      Tang, Patrick; Hasan, Mohammad R; Chemaitelly, Hiam; Yassine, Hadi M; Benslimane, Fatiha M; ... more authors ( Nature Researc , 2021 , Article)
      With the global expansion of the highly transmissible SARS-CoV-2 Delta (B.1.617.2) variant, we conducted a matched test-negative case-control study to assess the real-world effectiveness of COVID-19 messenger RNA vaccines ...
    • BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ( Elsevier , 2023 , Other)
      COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ...
    • Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRCA1/2 genes. 

      Rahman, Sumaya; Zayed, Hatem ( Elsevier , 2018 , Article)
      The GCC is an economic alliance of six Arab countries, including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE). The rate of endogamous marriage among the GCC countries is approaching 100%, with ...
    • Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients 

      Swapna, Thomas; Ouhtit, Allal; Al Khatib, Hebah A.; Eid, Ali H.; Mathew, Shilu; ... more authors ( Elsevier , 2022 , Article Review)
      Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ...
    • C-Reactive Protein in the Premature Rupture of the Membranes 

      El Taher, F. T.; Afifi, N. M.; Khadija, A. H.; Al Saad, A. H. ( Hamad bin Khalifa University Press (HBKU Press) , 2004 , Article)
      Premature rupture of the membranes (PROM) defined as a rupture of membranes before onset of labor, which is one of the most complications of pregnancy that leads to significant maternal and neonatal morbidity and mortality. ...
    • Cadmium induces migration of colon cancer cells: Roles of reactive oxygen species, p38 and cyclooxygenase-2 

      Naji, Sara; Issa, Khodr; Eid, Assaad; Iratni, Rabah; Eid, Ali H. ( Cell Physiol Biochem Press GmbH & Co KG , 2019 , Article)
      Background/Aims: Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. Methods: A ...
    • Can commercial automated immunoassays be utilized to predict neutralizing antibodies after SARS-CoV-2 infection? A comparative study between three different assays. 

      Ismail, Ahmed; Shurrab, Farah M; Al-Jighefee, Hadeel T; Al-Sadeq, Duaa W; Qotba, Hamda; ... more authors ( IMR , 2021 , Article)
      Background: High-throughput assays that can infer neutralizing activity against SARS-CoV-2 are of great importance for assessing the immunity induced by natural infection and COVID-19 vaccines. We aimed to evaluate the ...
    • Canavan disease: an Arab scenario. 

      Zayed, Hatem ( Elsevier Inc. , 2015 , Article)
      The autosomal recessive Canavan disease (CD) is a neurological disorder that begins in infancy. CD is caused by mutations in the gene encoding the ASPA enzyme. It has been reported with high frequency in patients with ...
    • Cancer Resistance to Immunotherapy: Comprehensive Insights with Future Perspectives 

      Said, Sawsan Sudqi; Ibrahim, Wisam Nabeel ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)
      Cancer immunotherapy is a type of treatment that harnesses the power of the immune systems of patients to target cancer cells with better precision compared to traditional chemotherapy. Several lines of treatment have been ...
    • CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion. 

      Ouhtit, Allal; Abdraboh, Mohammed E; Hollenbach, Andrew D; Raj, Madhwa H G (2017 , Article)
      We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate signaling ...
    • CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin 

      Ouhtit, Allal; Thouta, Rajesh; Zayed, Hatem; Gaur, Rajiv L; Fernando, Augusta; ... more authors ( Ivyspring International Publisher , 2020 , Article)
      Beyond their role in bone and lung homeostasis, mesenchymal stem cells (MSCs) are becoming popular in cell therapy. Various insults may disrupt the repair mechanisms involving MSCs. One such insult is smoking, which is a ...
    • Cellular immune activation in Sardinian middle-aged, older adults and centenarians 

      Sotgia, Salvatore; Zinellu, Angelo; Mangoni, Arduino A; Serra, Roberta; Pintus, Gianfranco; ... more authors ( Elsevier , 2017 , Article)
      In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum ...
    • Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2 

      Younes, Nadin; Al-Sadeq, Duaa W; Al-Jighefee, Hadeel; Younes, Salma; Al-Jamal, Ola; ... more authors ( MDPI , 2020 , Article)
      The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive strategy, including surveillance, diagnostics, research, ...