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Platforms Exploited for SARS-CoV-2 Vaccine Development.

Mathew, Shilu; Faheem, Muhammed; Hassain, Neeraja A; Benslimane, Fatiha M; Thani, Asmaa A Al; ... more authors ... less authors ( MDPI , 2020 , Article Review)

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin coronavirus (CoV) that has reached the pandemic stage. The virus uses its spike (S) glycoprotein to attach to the host cells ...

Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months

Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; ... more authors ... less authors ( Elsevier , 2021 , Article)

We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ...

Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage

Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ... less authors ( Nature Research , 2022 , Article)

There is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other ...

Rates of recurrent positive SARS-CoV-2 swab results among patients attending primary care in Qatar

Hamed, Ehab; Sedeeq, Saad; Alnuaimi, Ahmed Sameer; Syed, Mohamed; ElHamid, Mohamed Abd; ... more authors ... less authors ( Elsevier , 2021 , Article)

We read with interest the work of COCOREC (Collaborative study COvid RECurrences) study group.1 Recurrent positive rt-PCR results for SARS-CoV-2 infection were reported from early in the epidemic.1 , 2 , 3 , 4 , ...

Estimates of global SARS-CoV-2 infection exposure, infection morbidity, and infection mortality rates in 2020

Houssein H., Ayoub; Mumtaz, Ghina R.; Seedat, Shaheen; Makhoul, Monia; Chemaitelly, Hiam; ... more authors ... less authors ( Elsevier , 2021 , Article)

We aimed to estimate, albeit crudely and provisionally, national, regional, and global proportions of respective populations that have been infected with SARS-CoV-2 in the first year after the introduction of this virus ...

Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild-to-moderate SARS-CoV-2 in Qatar

Ahmed, Zaqout; Almaslamani, Muna A.; Chemaitelly, Hiam; Hashim, Samar A.; Ittaman, Ajithkumar; ... more authors ... less authors ( Elsevier , 2022 , Article)

ObjectivesTo estimate the real-world effectiveness of sotrovimab against severe, critical, or fatal COVID-19 in Qatar at a time in which most SARS-CoV-2 incidences occurred due to the BA.2 Omicron subvariant. MethodsWe ...

Analyzing inherent biases in SARS-CoV-2 PCR and serological epidemiologic metrics

Makhoul, Monia; Abou-Hijleh, Farah; Seedat, Shaheen; Mumtaz, Ghina R.; Chemaitelly, Hiam; ... more authors ... less authors ( springer nature , 2022 , Article)

Background: Prospective observational data show that infected persons with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain polymerase chain reaction (PCR) positive for a prolonged duration, and that ...

Prior Statins Use and Risk of Mortality and Severe Disease from COVID-19: A Systematic Review and Meta-Analysis

Yetmar, Zachary A; Chesdachai, Supavit; Kashour, Tarek; Riaz, Muhammad; Gerberi, Danielle J; ... more authors ... less authors ( Oxford University Press , 2021 , Article)

Background Statins up-regulate angiotensin converting enzyme-2, the receptor of SARS-CoV-2, while also exhibiting pleiotropic antiviral, antithrombotic and anti-inflammatory properties. Uncertainties exist about their ...

Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar’s experience

Bsat, Raghid; Chemaitelly, Hiam; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; ... more authors ... less authors ( International Society of Global Health , 2022 , Article)

Background: The effective reproduction number, Rt, is a tool to track and understand epidemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset ...

Modeling the population-level impact of treatment on COVID-19 disease and SARS-CoV-2 transmission

Monia, Makhoul; Abu-Hijleh, Farah; Ayoub, Houssein H.; Seedat, Shaheen; Chemaitelly, Hiam; ... more authors ... less authors ( Elsevier , 2022 , Article)

Different COVID-19 treatment candidates are under development, and some are becoming available including two promising drugs from Merck and Pfizer. This study provides conceptual frameworks for the effects of three types ...