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Editorial: Novel Targeted Therapy for Lung Cancer
(
OMICS International
, 2015 , Article)
Lung cancer accounts for about 27% of all cancer deaths and considered as the leading cause of cancer-associated death worldwide. Genotype-driven therapeutics is a standard of care for majority of subgroup of NSCLC patients ...
The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
(
Hindawi
, 2015 , Article)
Background. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate ...
Leptin And Free Leptin Receptor Is Associated With Polycystic Ovary Syndrome In Young Women
(
Hindawi Publishing Corporation
, 2015 , Article)
Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates
in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and ...
Oxidative Stress Markers In Gestational Diabetes Mellitus
(
De Gruyter
, 2015 , Conference Paper)
Oxidative stress is typically the result of an imbalance between the reactive oxygen species (ROS) and the antioxidant. The increased production of ROS could lead into some serious physiological problems on the cell, such ...
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
(
American Society for Biochemistry and Molecular Biology
, 2015 , Article)
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ...
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
(
Elsevier
, 2015 , Article)
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal ...