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Common and Rare Genetic Variants Associated With Alzheimer's Disease
(
WILEY PERIODICALS, INC.
, 2016 , Article)
Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ...
Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease
(
Bentham Science
, 2016 , Book chapter)
Alzheimer's disease (AD) is a complex neurodegenerative condition that is
clinically characterized by impaired cognitive functions. The major morphologically
observed lesion of AD encompasses the accumulation of extracellular ...
Human Olfactory Bulb Neural Stem Cells Expressing hNGF Restore Cognitive Deficit in Alzheimer's Disease Rat Model
(
Wiley
, 2015 , Article)
In this study, we aim to demonstrate the fate of allogenic adult human olfactory bulb neural stem/progenitor cells (OBNSC/NPCs)
transplanted into the rat hippocampus treated with ibotenic acid (IBO), a neurotoxicant ...
Gene Expression Profiling of Embryonic Human Neural Stem Cells and Dopaminergic Neurons from Adult Human Substantia Nigra
(
Public Library of Science
, 2011 , Article)
Neural stem cells (NSC) with self-renewal and multipotent properties serve as an ideal cell source for transplantation to treat neurodegenerative insults such as Parkinson’s disease. We used Agilent’s and Illumina Whole ...
Over-Expression of hNGF in Adult Human Olfactory Bulb Neural Stem Cells Promotes Cell Growth and Oligodendrocytic Differentiation
(
Public Library of Science ONE Staff
, 2013 , Article)
The adult human olfactory bulb neural stem/progenitor cells (OBNC/PC) are promising candidate for cell-based therapy for traumatic and neurodegenerative insults. Exogenous application of NGF was suggested as a promising ...