عرض بسيط للتسجيلة

المؤلفUllah, Asad
المؤلفMamun, Abdulla Al
المؤلفZaidi, Midhat Batool
المؤلفRoome, Talat
المؤلفHasan, Anwarul
تاريخ الإتاحة2023-10-08T08:41:45Z
تاريخ النشر2023
اسم المنشورBiomedicine and Pharmacotherapy
المصدرScopus
الرقم المعياري الدولي للكتاب7533322
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.biopha.2023.115156
معرّف المصادر الموحدhttp://hdl.handle.net/10576/48310
الملخصImpaired wound healing is a major healthcare problem in patients with diabetes often resulting in gangrene, microbial infection and amputation of affected limb. The delay or absence in healing process arises from several abnormalities, among them chronic hypoxia is a major concern due to its associated issues such as lack of collagen deposition, epithelization, fibroplasia, angiogenesis, and resistance to infections at the wound site. To address hypoxia, delivery of oxygen at the wound site through oxygen releasing agents have been proven to be effective therapeutics. Several oxygen releasing nanoparticles such as Sodium Percarbonate (SPC), Calcium Peroxide (CPO), Hydrogen Peroxide, Magnesium Peroxide (MPO) have been investigated in wound healing application. However, the uncontrolled/burst release of these nanotherapeutic agents and its accompanied cytotoxicity pose a barrier in expediting the healing process. In this study, a Chitosan-Polyvinyl alcohol (CS-PVA) based hydrogel containing oxygen releasing nanoparticle, calcium peroxide (CPO) was constructed to provide a slow and sustained delivery of oxygen for at least 5 days. In-vitro cell culture studies with this material using fibroblast and endothelial cell line exhibited improved biocompatibility, cell viability and enhanced proliferation in comparison with the control group. Additionally, cell migration study using scratch assay method showed superior cell migration ability of our proposed materials. Furthermore, In vivo study using diabetic rat model showed accelerated wound closure rate compared to untreated control wounds.
راعي المشروعThis article was made possible by the NPRP12S-0310-190276 grant funded by the Qatar National Research Fund (a part of the Qatar Foundation). Funding for Open Access publication fee was provided by the Qatar National Library. We also acknowledge the support provided by the Central Laboratories Unit (CLU), Qatar University, Qatar.
اللغةen
الناشرElsevier
الموضوعChronic hypoxia
Diabetic wound healing
Oxygen releasing materials
العنوانA calcium peroxide incorporated oxygen releasing chitosan-PVA patch for Diabetic wound healing
النوعArticle
رقم المجلد165
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة