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AuthorTayyem, Reema F.
AuthorBawadi, Hiba A.
AuthorShehadah, Ihab N.
AuthorAbu-Mweis, Suhad S.
AuthorAgraib, Lana M.
AuthorBani-Hani, Kamal E.
AuthorAl-Jaberi, Tareq
AuthorAl-Nusairr, Majed
AuthorHeath, Dennis D.
Available date2016-10-11T07:13:23Z
Publication Date2015-03-10
Publication NameNutrientsen_US
Identifierhttp://dx.doi.org/10.3390/nu7031769
CitationTayyem, R.F.; Bawadi, H.A.; Shehadah, I.N.; Abu-Mweis, S.S.; Agraib, L.M.; Bani-Hani, K.E.; Al-Jaberi, T.; Al-Nusairr, M.; Heath, D.D. Macro- and Micronutrients Consumption and the Risk for Colorectal Cancer among Jordanians. Nutrients 2015, 7, 1769-1786.
ISSN2072-6643
URIhttp://hdl.handle.net/10576/4861
AbstractOBJECTIVE: Diet and lifestyle have been reported to be important risk factors for the development of colorectal cancer (CRC). However, the association between total energy and nutrient intake and the risk of developing CRC has not been clearly explained. The aim of our study is to examine the relationship between total energy intake and other nutrients and the development of CRC in the Jordanian population. RESEARCH METHODS AND PROCEDURES: Dietary data was collected from 169 subjects who were previously diagnosed with CRC, and 248 control subjects (matched by age, gender, occupation and marital status). These control subjects were healthy and disease free. Data was collected between January 2010 and December 2012, using interview-based questionnaires. Logistic regression was used to evaluate the association between quartiles of total energy, macro- and micronutrient intakes with the risk of developing CRC in our study population. RESULTS: Total energy intake was associated with a higher risk of developing CRC (OR = 2.60 for the highest versus lowest quartile of intake; 95% CI: 1.21-5.56, p-trend = 0.03). Intakes of protein (OR = 3.62, 95% CI: 1.63-8.05, p-trend = 0.002), carbohydrates (OR = 1.41, 95% CI: 0.67-2.99, p-trend = 0.043), and percentage of energy from fat (OR = 2.10, 95% CI: 0.38-11.70, p-trend = 0.009) significantly increased the risk for the development of CRC. Saturated fat, dietary cholesterol and sodium intake showed a significant association with the risk of developing CRC (OR = 5.23, 95% CI: 2.33-11.76; OR = 2.48, 95% CI: 1.18-5.21; and OR = 3.42, 95% CI: 1.59-7.38, respectively), while vitamin E and caffeine intake were indicative of a protective effect against the development of CRC, OR = 0.002 (95% CI: 0.0003-0.011) and 0.023 (95%CI: 0.008-0.067), respectively. CONCLUSION: Our results suggest an increased risk for the development of CRC in subjects with high dietary intake of energy, protein, saturated fat, cholesterol, and sodium, and diets high in vitamin E and caffeine were suggestive of a protective effect against the risk of developing CRC. IMPACT: This is the first study in Jordan to suggest that it may be possible to reduce CRC risk by adjusting the intake of some macro-and micronutrients.
SponsorHigher Council of Science and Technology
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjectcolorectal cancer
Subjecttotal energy
Subjectmicronutrients
Subjectmacronutrient
TitleMacro- and micronutrients consumption and the risk for colorectal cancer among Jordanians
TypeArticle
Pagination1769-1786
Issue Number3
Volume Number7
dc.identifier.essn 2072-6643


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