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AuthorZafar, Aasma
AuthorKhan, Muhammad Jawad
AuthorNaeem, Aisha
Available date2023-11-05T06:14:29Z
Publication Date2023
Publication NameMolecular Biology Reports
ResourceScopus
ISSN3014851
URIhttp://dx.doi.org/10.1007/s11033-023-08512-3
URIhttp://hdl.handle.net/10576/49005
AbstractMurine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic reprogramming, apoptosis evasion, metastasis, and immunosuppression have been established. Alterations in the expression levels of MDM2 occur in multiple types of cancers resulting in uncontrolled proliferation. The cellular processes are modulated by MDM2 through transcription, post-translational modifications, protein degradation, binding to cofactors, and subcellular localization. In this review, we discuss the precise role of deregulated MDM2 levels in modulating cellular functions to promote cancer growth. Moreover, we also briefly discuss the role of MDM2 in inducing resistance against anti-cancerous therapies thus limiting the benefits of cancerous treatment.
SponsorAll the figures were generated using Biorender online application.
Languageen
PublisherSpringer Science and Business Media B.V.
SubjectApoptosis
Cell signaling
MDM2
Metabolism
TP53
TitleMDM2- an indispensable player in tumorigenesis
TypeArticle Review
Pagination6871-6883
Issue Number8
Volume Number50


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