عرض بسيط للتسجيلة

المؤلفDel Bo', Cristian
المؤلفPerna, Simone
المؤلفAllehdan, Sabika
المؤلفRafique, Ayesha
المؤلفSaad, Sara
المؤلفAlGhareeb, Fahad
المؤلفRondanelli, Mariangela
المؤلفTayyem, Reema F.
المؤلفMarino, Mirko
المؤلفMartini, Daniela
المؤلفRiso, Patrizia
تاريخ الإتاحة2023-11-05T06:14:30Z
تاريخ النشر2023
اسم المنشورNutrients
المصدرScopus
الرقم المعياري الدولي للكتاب20726643
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/nu15102250
معرّف المصادر الموحدhttp://hdl.handle.net/10576/49011
الملخصThe effectiveness of the Mediterranean diet (MD) in non-alcoholic fatty liver disease (NAFLD) subjects has been evaluated in several randomized controlled trials (RCTs). This systematic review and meta-analysis aimed to evaluate the overall effects of MD intervention in a cohort of NAFLD patients targeting specific markers such as central obesity, lipid profile, liver enzymes and fibrosis, and intrahepatic fat (IHF). Google Scholar, PubMed, and Scopus were explored to collect relevant studies from the last 10 years. RCTs with NAFLD subjects were included in this systematic review with a mean intervention duration from 6 weeks to 1 year, and different intervention strategies, mainly including energy restriction MD (normal or low glycaemic index), low-fat MD with increased monounsaturated and polyunsaturated fatty acids, and increased exercise expenditure. The outcomes measured in this meta-analysis were gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), total cholesterol (TC), waist circumference (WC), and liver fibrosis. Ten randomized controlled trials, which involved a total of 737 adults with NAFLD, were included. According to the results, the MD seems to decrease the liver stiffness (kPa) by –0.42 (CI95% –0.92, 0.09) (p = 0.10) and significantly reduce the TC by –0.46 mg/dl (CI95% –0.55, −0.38) (p = 0.001), while no significant findings were documented for liver enzymes and WC among patients with NAFLD. In conclusion, the MD might reduce indirect and direct outcomes linked with NAFLD severity, such as TC, liver fibrosis, and WC, although it is important to consider the variations across trials. Further RCTs are necessary to corroborate the findings obtained and provide further evidence on the role of the MD in the modulation of other disorders related to NAFLD.
راعي المشروعThe authors acknowledge the support of the APC central fund of the University of Milano.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعhuman interventions
lipid profile
liver function
Mediterranean diet
nonalcoholic fatty liver disease
العنوانDoes the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials
النوعArticle Review
رقم العدد10
رقم المجلد15
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة