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AuthorHasan, Anwarul
AuthorWaters, Renae
AuthorRoula, Boustany
AuthorDana, Rahbani
AuthorYara, Seif
AuthorAlexandre, Toubia
AuthorPaul, Arghya
Available date2016-10-24T09:37:53Z
Publication Date2016-03-08
Publication NameMacromolecular Bioscienceen_US
Identifierhttp://dx.doi.org/10.1002/mabi.201500396
CitationHasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci.,
ISSN1616-5187
URIhttp://hdl.handle.net/10576/4921
AbstractCardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not regenerate after myocardial infarction. The cardiac tissue is then replaced with nonfunctional fibrotic scar tissue rather than new cardiac cells, which leaves the heart weak. The limited proliferation ability of host cardiac cells has motivated investigators to research the potential cardiac regenerative ability of stem cells. Considerable progress has been made in this endeavor. However, the optimum type of stem cells along with the most suitable matrix-material and cellular microenvironmental cues are yet to be identified or agreed upon. This review presents an overview of various types of biofunctional materials and biomaterial matrices, which in combination with stem cells, have shown promises for cardiac tissue replacement and reinforcement. Engineered biomaterials also have applications in cardiac tissue engineering, in which tissue constructs are developed in vitro by combining stem cells and biomaterial scaffolds for drug screening or eventual implantation. This review highlights the benefits of using biomaterials in conjunction with stem cells to repair damaged myocardium and give a brief description of the properties of these biomaterials that make them such valuable tools to the field.
SponsorAnwarul Hasan acknowledges the startup grant and the University Research Board (URB) grant from American University of Beirut, Lebanon, and the National Council for Scientific Research (CNRS) grant, Lebanon, as well as the Farouk Jabre interdisciplinary research award. Arghya Paul acknowledges the University of Kansas New Faculty General Research Fund for support and assistance with this work. The authors also acknowledge an investigator grant provided by the Institutional Development Award (IDeA) from the National Institute of General Medical Sciences (NIGMS) of the NIH Award Number P20GM103638-04 (to A.P.). R.W. acknowledges the financial support from NIGMS (NIH, T32-GM008359) Biotechnology Predoctoral Research Training Program.
Languageen
PublisherWiley
Subjectangiogenesis
Subjecthydrogel
Subjectmyocardial infarction
Subjectnanomedicine
Subjectstem cells
TitleEngineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy
TypeArticle
Pagination958-977
Issue Number7
Volume Number16


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