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    The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis

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    Date
    2023
    Author
    Al-Maweri, Sadeq Ali
    Alhajj, Mohammed Nasser
    Halboub, Esam
    Tamimi, Faleh
    Salleh, Nosizana Mohd
    Al-Ak'hali, Mohammed Sultan
    Kassim, Saba
    Abdulrab, Saleem
    Anweigi, Lamyia
    Mohammed, Marwan Mansoor Ali
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    Abstract
    Background: A possible relationship between periodontitis (PD) and COVID-19 and its adverse outcomes has been suggested. Hence, the present systematic review and meta-analysis aimed to investigate the available evidence regarding the potential association between periodontitis (PD) and COVID-19 and its adverse outcomes. Materials and methods: PubMed, Scopus, Web of Science, and Google Scholar were searched for relevant studies published up to April 15th, 2023. Studies that evaluated the association between PD and COVID-19 were included. Risk of bias was evaluated by two reviewers, and meta-analyses were performed using RevMan 5.3 software. Results: A total of 22 studies involving 92,535 patients from USA, Europe, Asia, the Middle East and South America were included; of these, 12 were pooled into the meta-analysis. Most of the studies (19 studies) reported a significant association between PD and COVID-19. The pooled data found a significant association between PD and COVID-19 outcomes: more severe symptoms (OR = 6.95, P = 0.0008), ICU admissions (OR = 3.15, P = 0.0001), and mortality (OR = 1.92, P = 0.21). Additionally, compared to mild PD, severe PD was significantly associated with higher risks of severe COVID-19 outcomes: severe symptoms (P = 0.02); ICU admission (P = 0.0001); and higher mortality rates (P = 0.0001). The results also revealed 58% higher risk for COVID-19 infection in patients with PD (P = 0.00001). Conclusions: The present findings suggest a possible association between poor periodontal health and the risk of poor COVID-19 outcomes. However, owing to the observed methodological heterogeneity across the included studies, further prospective cohort studies with standardized methodologies are warranted to further unravel the potential association between periodontal disease and COVID-19 and its adverse outcomes.
    DOI/handle
    http://dx.doi.org/10.1186/s12903-023-03378-0
    http://hdl.handle.net/10576/49396
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    • COVID-19 Research [‎848‎ items ]
    • Dental Medicine Research [‎410‎ items ]

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