عرض بسيط للتسجيلة

المؤلفAl-Fahdawi, Mohamed Qasim
المؤلفRasedee, Abdullah
المؤلفAl-Qubaisi, Mothanna Sadiq
المؤلفAlhassan, Fatah H.
المؤلفRosli, Rozita
المؤلفEl Zowalaty, Mohamed Ezzat
المؤلفNaadja, Seif-Eddine
المؤلفWebster, Thomas J.
المؤلفTaufiq-Yap, Yun Hin
تاريخ الإتاحة2016-11-06T07:59:18Z
تاريخ النشر2015-09-10
اسم المنشورInternational Journal of Nanomedicineen_US
المعرّفhttps://doi.org/10.2147/IJN.S82586
الاقتباسAl-Fahdawi MQ, Rasedee A, Al-Qubaisi MS, et al. Cytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles. International Journal of Nanomedicine. 2015;10:5739-5750.
الرقم المعياري الدولي للكتاب1176-9114
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4971
الملخصIron–manganese-doped sulfated zirconia nanoparticles with both Lewis and Brønsted acidic sites were prepared by a hydrothermal impregnation method followed by calcination at 650°C for 5 hours, and their cytotoxicity properties against cancer cell lines were determined. The characterization was carried out using X-ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy, Brauner–Emmett–Teller (BET) surface area measurements, X-ray fluorescence, X-ray photoelectron spectroscopy, zeta size potential, and transmission electron microscopy (TEM). The cytotoxicity of iron–manganese-doped sulfated zirconia nanoparticles was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays against three human cancer cell lines (breast cancer MDA-MB231 cells, colon carcinoma HT29 cells, and hepatocellular carcinoma HepG2 cells) and two normal human cell lines (normal hepatocyte Chang cells and normal human umbilical vein endothelial cells [HUVECs]). The results suggest for the first time that iron–manganese-doped sulfated zirconia nanoparticles are cytotoxic to MDA-MB231 and HepG2 cancer cells but have less toxicity to HT29 and normal cells at concentrations from 7.8 µg/mL to 500 µg/mL. The morphology of the treated cells was also studied, and the results supported those from the cytotoxicity study in that the nanoparticle-treated HepG2 and MDA-MB231 cells had more dramatic changes in cell morphology than the HT29 cells. In this manner, this study provides the first evidence that iron–manganese-doped sulfated zirconia nanoparticles should be further studied for a wide range of cancer applications without detrimental effects on healthy cell functions.
اللغةen
الناشرDove Press
الموضوعHT29 cells
الموضوعLewis and Brønsted acidic sites
الموضوعanticancer applications
الموضوعnanopartices
الموضوعtransition metal oxide
العنوانCytotoxicity and physicochemical characterization of iron–manganese-doped sulfated zirconia nanoparticles
النوعArticle
الصفحات5739-5750
رقم العدد1
رقم المجلد10
ESSN1178-2013


الملفات في هذه التسجيلة

Icon

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة